Table 2 Polymorphisms at miRNA and miRNA processing genes and risk of leukoplakia (Only SNPs with significant p-values are shown)
Gene (SNP)c | Genotype and Alleles | Control (%)/leukoplakia (%) | O.R (95% C.I)a | p- value |
|---|---|---|---|---|
Gemin3(rs197412) | TT + CT | 389(87)/ 273(92) | Ref | 0.03 |
CC | 58(13)/ 25(8) | 0.5(0.3–0.9) | ||
T | 580(62)/ 417(70) | Ref | 0.04 | |
C | 314(38)/ 179(30) | 0.7(0.6–0.9) | ||
mir34b(rs2187473) | CC | 153(35)/ 116(41) | Ref | 0.05 |
CT + TT | 286(65)/ 166(59) | 0.7(0.5–0.9) | ||
C | 527(60)/ 357(63) | Ref | 0.29 | |
T | 351(40)/ 207(37) | 0.8 (0.7–1.1) | ||
Within Tobacco Stratified Individuals | ||||
(bTobacco Smokers : Controls- 267/Leukoplakia-255) | ||||
Gemin3(rs197412) | TT + CT | 222(86)/230(92) | Ref | 0.05 |
CC | 35(14)/21(8) | 0.58(0.3–1) | ||
mir34b(rs2187473) | CC | 80(32)/98(41) | Ref | 0.04 |
CT + TT | 169(68)/140(59) | 0.68(0.5–0.9) | ||
(bTobacco Chewers : Controls-277/Leukoplakia-129) | ||||
mir29a(rs24168) | GG + AG | 228(84)/78(74) | Ref | 0.05 |
AA | 44(16)/27(26) | 1.8(1–3) | ||