From: Pentacycloundecane lactam vs lactone norstatine type protease HIV inhibitors: binding energy calculations and DFT study
Peptide
IC 50 with lactam-NH- (μM)*
IC 50 with lactone-CO- (μM)*
Mixture of both diastereomers
Glu-Ala-Ile-Ser
0.078 ± 0.0035
0.85 ± 0.18