Figure 4

Effect of telomerase deficiency on extracellular matrix (ECM) protein molecules during in vitro osteoblast differentiation of BMSCs. A) Differential expression of genes involved in cell differentiation into ostoeblasts. B-E) Differential gene expression profiles of molecules involved in extracellular matrix production in Terc ^-/- BMSCs – notable genetic molecules were related with ECM collagens, basement membrane constituents, ECM proteases, ECM protease inhibitors and other molecules associated with ECM. Genes that were not amplified or not detectable in the PCR array were marked as ‘n.d’ (not detectable). Osteogenic super array data are represented as fold change relative to WT controls of three independent biological replicates pooled together.