Table 4 The differences of the single nucleotide polymorphisms in the RUNX3 , and TFF2 genes between children of gastric cancer patients with (N = 31) or without (N = 18) SPEM

Age (yr)

39.9 ± 7.7

38.2 ± 11.3

0.312

Gender (F: M)

20 (65): 11 (35)

7 (39): 11 (61)

0.092

0.136

2.9 (0.9 - 9.5)

RUNX3

  RUNX3 -18508

(N = 29)

(N = 17)

  C-carrier: GG

21 (72): 8 (28)

12 (71): 5 (29)

0.897

1.000

1.1 (0.3 - 4.1)

  RUNX3 -1714

(N = 31)

(N = 18)

  A-carrier: CC

16 (52): 15 (48)

4 (22): 14 (78)

0.044

0.067

3.7 (1.0 - 13.9)

  RUNX3 -1582

(N = 30)

(N = 18)

  T-carrier: CC

16 (53): 14 (47)

5 (28): 13 (72)

0.085

0.137

3.0 (0.8 - 10.4)

  RUNX -1166

(N = 31)

(N = 18)

  C-carrier: TT

16 (52): 15 (48)

4 (22): 14 (78)

0.044

0.070

3.7 (1.0 - 13.9)

  RUNX3 +492

(N = 30)

(N = 18)

  A-carrier: TT

16 (53): 14 (47)

4 (22): 14 (78)

0.035

0.042

4.0 (1.1 - 15.0)

  RUNX3 +73375

(N = 30)

(N = 18)

  C-carrier: AA

21 (70): 9 (30)

14 (78): 4 (22)

0.613

0.741

0.7 (0.2 - 2.6)

TFF2

  TFF2 -1373

(N = 30)

(N = 18)

  C-carrier: TT

30 (100): 0 (0)

17 (94): 1 (6)

0.206

0.377

2.6 (0.8 - 9.2)

  TFF2 -503

(N = 30)

(N = 18)

  AA: G-carrier

23 (77): 7 (23)

10 (56): 8 (44)

0.127

0.194

2.6 (0.7 - 9.2)

  TFF2 -308

(N = 30)

(N = 18)

  CC: A-carrier

18 (60): 12 (40)

5 (28): 13 (72)

0.022

0.041

3.9 (1.1-13.8)

  TFF2 +4649

(N = 30)

(N = 18)

  G-carrier: AA

26 (87): 4 (13)

17 (94): 1 (6)

0.419

0.637

0.4 (0.1-3.7)

RUNX3+492/TFF2-308

 A-carrier/CC

  2R

7 (23)

1 (6)

0.001

0.009

23.3 (2.0 - 273.3)

  1R

20 (67)

7 (39)

0.001

0.004

9.5 (2.0 - 44.9)

  0R

3 (10)

10 (56)

1

  2R+1R:0R

27 (90): 3 (10)

8 (44): 10 (56)

3×10^-4

0.001

11.3 (2.5 - 51.0)