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Fig. 2 | Journal of Biomedical Science

Fig. 2

From: Drosophila mitochondrial topoisomerase III alpha affects the aging process via maintenance of mitochondrial function and genome integrity

Fig. 2

Mitochondrial Top3α is required for mitochondrial genome maintenance and energy generation. a M1L flies exhibit lower mtDNA copy numbers than controls at the ages examined. b The decrease of mitochondrial membrane potential is accelerated in M1L flies compared to wildtype and rescued flies. c ATP content in M1L flies declines more rapidly with age when compared to wildtype and rescued counterparts. Two-way ANOVA with Turkey’s multiple tests was used for statistical analysis. (NS = not significant, ***P < 0.001, **P < 0.01, *P < 0.05)

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Journal of Biomedical Science

ISSN: 1423-0127