Fig. 2

C19MC miRNAs harboring the AAGUGC hexameric sequence. a The sixteen C19MC miRNAs that share the AAGUGC hexameric seed sequence (in bold letters and boxed in red) with the miR-302 (in blue letters) and miR-372 (in green letters) families are shown. MiRNAs that have the AAGUGC seed sequence in the canonical nucleotides 2-7 position are called group I; other miRNAs in non-canonical position are called group II, with IIa and IIb subgroups as depicted. *miRNAs are in the 3p configuration as in the miRBase ver 21. **The existence of miR-1323-3p is based on computational prediction. b Phylogenic tree of all C19MC miRNAs reconstructed with the precursors of the miRNAs. Groups I, IIa and IIb are AAGUGC-harboring miRNAs as defined in (b) above (see text for further description)