Mild to Moderate Disease (IC) | Severe Disease - Critical Limb Ischemia |
---|---|
Oxidative stress mainly in type II fibres [6] | |
↔/↓ capillary density, ↓ ABI (0.5–0.8) | ↓↓ ABI (<0.4) [141] |
↓ mitochondrial volume [163] | Mitochondriopathy [141] |
Fibrosis, Fat accumulation, different myofibre sizes but ↓↓ CSA [27] |