Fig. 1
![Fig. 1](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12929-022-00867-2/MediaObjects/12929_2022_867_Fig1_HTML.png)
Schematic diagram of the study design. A Data of human samples of colorectal adenocarcinoma were obtained from public databases (see Additional file 1: Table S1 and Supplementary Methods). B A risk model is established by integrating module analysis and Cox regression. C The risk model is evaluated by independent prognosis analysis and a nomo decision tree is established by integrating risk score and other clinical parameters. D The risk model is validated in another independent large cohort of colon cancer; molecular classification, therapy evaluation and pathway enrichment analysis of the risk genes is investigated. E Tumor microenvironment immune activity is correlated with the risk model