Fig. 3
![Fig. 3](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12929-022-00867-2/MediaObjects/12929_2022_867_Fig3_HTML.png)
Survival and Hazard ratio analysis based on risk model genes. A Panels above: ranked patients by risk score and relative survival visualization. Panel below: heatmap of expression level of 23 risk model genes is shown in the indicated ranked patients. Risk groups are identified by the median risk score. *Differentially expressed between low-risk group and high-risk group (p-value is calculated by Wilcoxon test, FDR-adjusted p < 0.05). B Kaplan–Meier survival analysis in low- and high-risk group categorized by risk score in TCGA-COAD cohort (n = 334). C AUC (area under the ROC curve) of five-year survival predicted by risk score and all the other clinical parameters. TNM staging system is used to describe the amount and spread of cancer in a patient’s body. T: the size of the original (primary) tumor and whether it has invaded nearby tissue; N: spread of cancer to nearby lymph nodes; M: distant metastasis (spread of cancer from one part of the body to another). D Forest plot of Hazard ratios with 95% confidence intervals of the indicated risk factors is obtained with both univariant (above) and multivariant (below) Cox regression method. E Kaplan–Meier survival analysis in another independent cohort of colon cancer (GS39582E, n = 562)