Fig. 1

Dysregulated circadian genes in mice and human with circadian rhythm disruption. a The relative mRNA level of clock genes (Rev-erbα, Rev-erbβ, Bmal1) in uterus of mice with normal sleep in 24 h. White box represented light-on time. Black box represented light-off time. b The relative mRNA level of clock genes in uterus of mice with normal or sleep disturbance at ZT3 (three hours after light-on) and ZT9. c the number of patients with infertility or history of unexplained abortion and those with sleep disturbance. d The relative mRNA level of clock genes in ESCs of human with normal or sleep disturbance. mNS represented mouse with normal sleep. mSD represented mouse with sleep disturbance. hNS represented human with normal sleep. hSD represented human with sleep disturbance. The time of light on referred to ZT0. Data represented Mean ± SEM. Statistical analysis was performed using Student’s t‐test. *P < 0.05, **P < 0.01, ***P < 0.001