Fig. 8
From: Secretory autophagy promotes Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1
Autophagy promotes active-form Rab37-mediated exocytosis of TIMP1, which suppresses lung cancer cell motility. Autophagy involves degradative and secretory pathways. Rab37 is an upstream regulator of autophagic activity and TIMP1 secretion. Starvation induced active-form Rab37 increases not only TIMP1 secretion but also autophagic activity to promote TIMP1 secretion. Secretory autophagy-mediated TIMP1 secretion is Rab37- and Sec22b-dependent. Secretory autophagy-promoted TIMP1 exocytosis suppresses lung cancer cell motility both in vitro and in vivo