Fig. 5From: Conformational alteration in glycan induces phospholipase Cβ1 activation and angiogenesisThe proposed molecular mechanism for GHCer-induced enhancement of angiogenic activity in tumor microenvironment. The fucose residue of GHCer not only affects its interaction with TRAX at low energy conformation to form stable GHCer/TRAX complex, but also generate several H bondings and hydrophobic interactions with TRAX protein. In addition, GHCer competes with PLCβ1 for binding to TRAX, leading to the dissociation of PLCβ1 to the cytosol and enhancement of angiogenesis in tumor microenvironmentBack to article page