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Fig. 5 | Journal of Biomedical Science

Fig. 5

From: Acetaldehyde via CGRP receptor and TRPA1 in Schwann cells mediates ethanol-evoked periorbital mechanical allodynia in mice: relevance for migraine

Fig. 5

Schematic representation of the pathway that signals cutaneous allodynia elicited by the ethanol (EtOH) metabolite, acetaldehyde (ACD). ACD, by targeting TRPA1, releases CGRP from trigeminal nerve terminals that activate CLR/RAMP1 on Schwann cells. CLR/RAMP1 activation elicits a transient cAMP-mediated protein kinase A (PKA) phosphorylation of endothelial nitric oxide synthase (eNOS). The ensuing nitric oxide (NO) release targets the oxidant-sensitive channel, TRPA1, in Schwann cells, which sustains and amplifies reactive oxygen species (ROS) generation. The persistent oxidative stress signals mechanical allodynia via TRPA1 on adjacent nerve fibers. ADH alcohol dehydrogenase

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Journal of Biomedical Science

ISSN: 1423-0127