Fig. 6

Diosgenin altered gut microbes in mice. A Gut microbiota data of four groups were visualized by principal co-ordinates analysis. B The bacterial composition of the four groups at the phylum level. C The abundance of Desulfovibrionaceae in the four groups. D The bacterial composition of the four groups at the genus level. E Firmicutes/Bacteroidetes ratio of the four groups. F Serum IL6 in mice injected with LPS. G Intestinal expression of protein levels of NPC1L1 and STAT3 phosphorylation in mice injected with LPS. The gray value ratio was plotted on the side. Data are expressed as mean ± SEM (n = 7 in each group in A-E, n = 5 in each group in F, G). *P < 0.05, **P < 0.01, ****P < 0.0001. LD: lithogenic diet; LD-1DG: LD + 1% diosgenin; LD-2DG: LD + 2% diosgenin; LD-EZM: LD + ezetimibe