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Fig. 7 | Journal of Biomedical Science

Fig. 7

From: Krüppel-like factor 10 modulates stem cell phenotypes of pancreatic adenocarcinoma by transcriptionally regulating notch receptors

Fig. 7

KLF10/Notch signal pathway in modulating proliferation and stemness of PDAC. Loss of KLF10, due to epigenetic, transcriptional regulation or protein degradation in PDAC, interferes the balance of ELF3 and KLF10 competing for activation and suppression, respectively, of the Notch-3 and -4 promoter activity which modulates cancer cell proliferation and stemness phenotypes. Elevating KLF10 expression level by metformin, upregulating Notch 3 transcription by evodiamine or NICD by DAPT, ameliorates PDAC progression induced by KLF10 deficiency

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Journal of Biomedical Science

ISSN: 1423-0127