Fig. 7
From: Self-healing hydrogel as an injectable implant: translation in brain diseases
A BMSCs loaded in composite self-healing hydrogel (“scaffolds” in figure) ameliorated ischemic stroke. The effects of BMSCs and BMSC-loaded self-healing hydrogel (“BMSCs + scaffolds” in figure) were assessed by TTC staining. Reprinted with permission from [118]. Copyright © 2023 Pei et al. First published by Elsevier Ltd. B Efficacy of the CH hydrogel in alleviating the brain atrophy and neurological deficits in the ICH rat model. Reprinted with permission from [21]. Copyright © 2020 American Chemical Society. C The capabilities of conductive self-healing hydrogels (COA2 hydrogel) injected in the brain of PD rats to protect dopaminergic neurons/fibers, to reduce neural inflammation, and to improve motor functions. TH: tyrosine hydroxylase. GFAP: glial fibrillary acidic protein. Reprinted with permission from [132]. Copyright © 2023 Xu et al. First published by BioMed Central Ltd. D Schematic representation of the systemic process of inflammation in AD neuroinflammation. Reprinted with permission from [139]. Copyright © 2021 Cunha et al. First published by Dove Medical Press Ltd. E Tissue regeneration status of TBI rat brain after the self-healing hydrogel injection for 21 days. Reprinted with permission from [160]. Copyright © 2022 Wiley‐VCH GmbH