Table 1 The representative self-healing hydrogels utilized for treating various brain diseases
From: Self-healing hydrogel as an injectable implant: translation in brain diseases
Type of brain diseases | Hydrogel composition | Self-healing mechanism | Study design | Role of hydrogel | Refs. |
|---|---|---|---|---|---|
Ischemic stroke | GC/DFPEG | Schiff base | Rat MCAO model | Cell carrier (rat BMSC) | [118] |
Hemorrhagic stroke | GC/DFPEG/HA | Schiff base with SIPN | Rat ICH model | Tissue scaffold | [21] |
Parkinson’s disease | l-glutamine amide derivative/benzaldehyde | Supramolecular interaction and Schiff base | Mouse PD model | Drug carrier for nasal delivery | [131] |
Parkinson’s disease | CMC/OTA@Au | Schiff base | Rat PD model | Tissue scaffold | [132] |
Alzheimer’s disease | No practical self-healing hydrogel has obviously treatment efficiency verified through in vivo test for AD | ||||
Traumatic brain injury | HA-PBA/Gel-Dopa | Boronate ester | Rat brain TBI model | Tissue scaffold | [160] |