Fig. 6

B7-1 and B7-2 dimer interface mimetic peptides attenuate signaling through CD28 and inflammatory cytokine production. A–F Human PBMC were induced with αCD3/αCD28 monoclonal antibodies alone (open symbols) or in the presence of pB1-8 (A, B), pB1-78 (C, D) or pB2-7 (E, F) at concentrations shown (µg/mL) (filled symbols). At times shown, IL-2 and TNF-α in culture medium were quantitated. PBMC from three distinct human donors were used to generate the data in A–F, respectively. Representative data of 3 experiments are shown