Fig. 7

At doses submolar to toxin, CD28 and B7-1 dimer interface mimetic peptides protect mice from lethal superantigen challenge. A Mice were injected with SEB alone (n = 15 per group) (open symbols) or together with 0.04 µg p4TA (n = 14 per group) (black symbols); p for survival, 0.062. B Mice (n = 5 per group) were injected with SEB alone or together with 0.045 µg p5TA (grey symbols) or 0.09 µg p5TA (black symbols); p for survival, 0.029. C Mice (n = 5 per group) were injected with SEB alone or together with 0.052 µg pB1-78 (black symbols); p for survival, 0.192. D Protein sequences of human and mouse CD28 and CD80, aligned by EMBOSS Needle. Sequences shown are portions of human (P10747) and mouse (P31041) CD28 and of human (P33681) and mouse (Q3U4B5) CD80. Dimer interface contacts in p4TA, p5TA and pB1-78 are shown in red, non-contact residues are shown in green if identical and in black if non-identical