Fig. 1

Enrichment rationale and applications. A Different conditions and choice of gene editing technology influence gene editing efficiencies. These are ordered based on their approximate impact on genome editing efficiency, but can be subject to high variability. B Applications for enrichment of gene edited cells include engineering of cell and animal models, engineering and isolation of single cell clones, editing of hard-to-edit cell types, making new gene editing tools more applicable, and facilitating the use of gene editing in gene and cellular therapies