Fig. 1
From: Liver in infections: a single-cell and spatial transcriptomics perspective
Anatomical structure, composition, and function of the liver. A Arterial supply to the liver and portal venous drainage. B Anatomical structure and cellular composition of hepatic lobules. C Single-cell RNA sequencing has revealed gradients of gene expression along the three different zones of hepatic lobule in different cell lineages, enabling the differentiation of portal zone and central zone hepatocytes, LSECs, and HSCs. These markers are shown in Figure. D Main functions of the liver. ALB albumin, ADAMTSL2 ADAMTS-like protein 2, CYP2E1 cytochrome P450 2E1, DLL4 Delta-like protein 4, ECAD E-cadherin, EFNB2 ephrin-B2, GSS glutathione synthetase, HSC hepatic stellate cell, ITGB3 integrin β3, KIT mast/stem cell growth factor receptor Kit, LSEC liver sinusoidal endothelial cell, NGFR tumour necrosis factor receptor superfamily member 16, Rspo3 R-spondin-3, THBD thrombomodulin, WNT2 wingless-type MMTV integration site family member 2