Fig. 4
Structural comparison of scFv apo form and in complex with U1 peptide. A Stereo image of the apo structure of scFv AU1 depicting two molecules in the asymmetric unit. The CDR regions, variable heavy chain (VH) and variable light chain (VL), are shown in magenta and orange, respectively. B Stereo image of scFv AU1 in complex with extended U1 peptide in cartoon representation. Peptide monomers (F and G) are shown in red and blue colors. C, D Surface representation of scFv AU1 apo form and in complex with extended U1 peptide. The two peptide molecules snugly fit in a cavity between the CDR regions of the scFv molecule. E Interactions of the extended U1 peptide with scFv AU1 are shown in stereo mode. F Fo-Fc omit map of peptide dimer. The side chains of some residues were not modeled due to poor electron density