Table 4 Mutated and methylated genes in HNSCC ctDNA

TP53

Burgener et al. [13]; Flach et al. [37]; Galot et al. [43]; Khandelwal et al. [69]; Kogo et al. [72]; Mes et al. [99]; Perdomo et al. [115]; Porter et al. [118]; van Gink et al. [156]; Wilson et al. [165]

PIK3CA

Burgener et al. [13]; Galot et al. [43]; Liebs et al. [83]; Porter et al. [118],

MYC

Burgener et al. [13]; Galot et al. [43],

CDKN2A

Galot et al. [43]; Mes et al. [99],

NRAS

Braig et.al., [12]; Wilson et al. [165],

EGFR

Galot et al. [43]; Wilson et al. [165],

NOTCH1

Burgener et al. [13]; Mes et al. [99],

FAT1

Burgener et al. [13]; Liebs et al. [83],

BRCA1, KIT, BRAF, ESR1, FGFR2, FGFR3, MAP2K1, ARID1A, ATM, MET

Wilson et al. [165],

ACACA, ATR, LAMA2, SMARCA4, RELN, PDGFRA, EZH2

Liebs et al. [83],

CASP8, NSD1, KMT2D,

Mes et al. [99],

KRAS, HRAS

Braig et.al. [12],

GRIN3A

Burgener et al. [13],

FBXW7

Khandelwal et al. [69],

Methylated genes in ctDNA

 CDKN2A

Sanchez et al. [127]; Tian et al. [150],

 DAPK1

Sanchez et al. [127]; Tian et al. [150],

 CCNA1, DAPK, CDH8, TIMP3

Jesus et al. [29],

 PENK, NXPH1, ZIK1, TBXT, CDO1

Patel et al. [112],

 EDNRB, p16, DCC

Mydlarz et al. [102],

 RASSF1, DLEC1, UCHL1

Tian et al. [150],

 MGMT, GSTP1

Sanchez et al. [127],

 SHOX2, SEPT9

Schröck et al. [132],