From: Brain alarm by self-extracellular nucleic acids: from neuroinflammation to neurodegeneration
SENA | Study population | Sample type | RNA/DNA name | Findings | References |
---|---|---|---|---|---|
miRNA | 73 HC 75 PD | Plasma | miR-153 | Downregulated in PD patients compared to HC Expression positively correlates with disease duration and severity | [415] |
78 HC 78 PD | PBMC | miR- 34a, miR-125a | Reduced in PD patients Expression inversely correlates with disease severity | [429] | |
50 HC 68 PD | Serum | miR-374a-5p | Decreased in PD patients Expression is negatively correlated with disease severity | [176] | |
126 HC 148 PD | Serum | miR-30c-5p, miR-373 | Upregulated in PD patients Expression positively correlates with disease severity | [454] | |
44 HC 82 PD | Serum | miR-132-3p, miR-146a-5p | Decreased in PD patients Expression negatively correlates with disease severity | [341] | |
14 HC 15 PD | Plasma-derived pure small extracellular vesicles | miR‑34a‑5p | Downregulated in PD patients Expression inversely correlates with disease duration and severity | [136] | |
14 HC 30 PD | PBMC | miR-27a-3p | Decreased in PD patients (all stages) Expression negatively correlates with disease severity | [104] | |
miR-27b-3p | Increased in PD patients (early stage) Expression decreased along with the disease severity | ||||
24 HC 23 PD | Serum | miR-214 | Upregulated in early stage PD patients Expression negatively correlates with disease duration, severity of anxiety and non-motor symptoms | [426] | |
60 HC 80 PD | Serum | miR-150 | Reduced in PD patients Expression inversely correlates with blood levels of pro-inflammatory cytokines | [212] | |
25 HC 33 PD | PBMC | miR-376a | Increased in PD patients Expression positively correlates with disease severity | [17] | |
16 HC 36 PD | PBMC | miR-885, miR-17 | Upregulated in PD patients Expression positively correlates with disease severity | [24] | |
miR-361 | Downregulated in PD patients Expression positively correlates with disease severity | ||||
222 HC 269 PD | Plasma | miR-132 | Increased in PD patients Expression is positively related with the disease duration and severity | [433] | |
43 HC 37 PD | PBMC | miR-155-5p | Elevated in PD patients Downregulation by L-dopa treatment | [38] | |
80 HC 80 PD | Serum | miR-29a, miR-29c | Decreased in PD patients Expression negatively correlates with disease severity | [18] | |
42 HC 44 PD | CSF | miR-144-5p, miR-200a-3p, miR-542-3p | Upregulated in PD patients Expression is positively associated with disease severity | [270] | |
112 HC 138 PD | Serum | miR-221 | Reduced in PD patients Expression positively correlates with disease severity | [247] | |
lncRNA | 84 HC 97 PD | Serum | TUG1 | Upregulated in PD patients compared to HC Expression positively correlates with disease severity and blood levels of pro-inflammatory cytokines | [54] |
13 HC 32 PD | Plasma-derived exosomes | MKRN2–42:1 | Decreased in PD patients Expression is positively associated with disease severity | [395] | |
196 HC 228 PD | Serum | MALAT1 | Increased in PD patients Expression positively correlates with cognitive impairment, motor symptoms severity and blood levels of pro-inflammatory cytokines | [428] | |
78 HC 78 PD | PBMC | ANRIL | Elevated in PD patients Expression positively correlates with disease severity | [429] | |
30 HC 30 PD | Plasma | MEG3 | Decreased in PD patients Expression negatively correlates with disease stage, severity of non-motor symptoms and cognitive decline | [314] | |
85 HC 93 PD | Neuronal-derived plasma exosomes | linc-POU3F3 | Upregulated in PD patients Expression positively correlates with disease stage, motor symptoms severity and cognitive impairment | [484] | |
93 HC 99 PD | Serum | RMST | Increased in PD patients Expression positively correlates with disease severity and blood levels of pro-inflammatory cytokines | [47] | |
circRNA | 100 HC 300 PD | Plasma | circ_0085869, circ_0004381, circ_0017204, circ_0090668 | Upregulated in PD patients (all stages) compared to HC Increased in early PD (stage 1) patients compared to HC Elevated levels in late PD (stage 2–5) compared to early PD (stage 1) patients | [472] |
40 PD | Plasma | circEPS15 | Expression inversely correlates with motor symptoms severity | [476] | |
6 HC 6 PD | Whole blood-derived exosomes | circ_0001535 circ_0000437 | Elevated in PD patients Reduced in PD patients after 2-week multidisciplinary rehabilitation | [92] | |
cfDNA | 20 HC 20 PD | CSF | 8-OHdG (oxidized cfDNA) | Increased concentration in PD patients Concentration positively correlated with duration of disease | [166] |
10 HC 56 PD | CSF | mtDNA | Reduced copy number in PD patients compared to HC No correlation with cognitive impairment | [310] | |
262 HC 363 PD | Peripheral white blood cells | mtDNA | Decreased copy number in PD patients No correlation with cognitive impairment | [309] | |
12 HC 21 PD | CSF | mtDNA | Reduced copy number in PD patients compared to HC Higher proportion of mtDNA molecules with deletions in PD patients | [308] |