Fig. 2
From: Broadly neutralizing human antibodies against Omicron subvariants of SARS-CoV-2
Characteristics of 38 SARS-CoV-2 Omicron BA.5-neutralizing antibodies derived from memory B cells of convalescent donors. A Heatmap shows the pseudovirus neutralization activities for the subset of antibodies (n = 38) with observable neutralizing activities (IC50 < 1000 ng/mL) against Omicron BA.5. The colors indicate the range of IC50: red, < 20 ng/mL; yellow, 20–100 ng/mL; green 100–1000 ng/mL. B The gene family usages of VH and VL for the 38 identified neutralizing antibodies against BA.5-RBD protein. C The amino acid lengths of the CDR3 loop of VH and VL for the 38 antibodies. D Rates of nucleotide substitutions in VH and VL for the 38 antibodies. E Pseudovirus neutralization activities of the 16 most potent antibodies (IC50 < 20 ng/mL) against Omicron BA.5, BQ.1.1 and XBB.1 subvariants. The 16 antibodies were renamed sequentially from RBD-hAb-B22 to RBD-hAb-B37