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Fig. 9 | Journal of Biomedical Science

Fig. 9

From: Exosomal PGE2 from M2 macrophages inhibits neutrophil recruitment and NET formation through lipid mediator class switching in sepsis

Fig. 9

Working model. Our data demonstrated that exosomal PGE2 from M2 macrophages functions on the EP4 receptor to increase 15-LO expression in PMNs, upregulate LXA4 production to downregulate PMN CXCR2 and ROS expressions, inhibit the capacity of PMN migration and NET formation, alleviate lung injury, and reduce mortality in sepsis. The graph was drawn on the Figdraw online website (Export ID: RYUYR79822)

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Journal of Biomedical Science

ISSN: 1423-0127