Fig. 7From: Phenotypic heterogeneity in human genetic diseases: ultrasensitivity-mediated threshold effects as a unifying molecular mechanismELT-2 regulation as an example of the three requirements for phenotypic heterogeneity due to ultrasensitivity mediated threshold response. In Skn-1 mutants, the ELT-2 positive feedback is weakened due to absence of END-3 and reduced END-1. The ELT-2 level may fall below its functional threshold in some individuals, causing a failure in in C. elegans intestinal development. Modified from [56]Back to article page