Various arrangements of mobile genetic elements among CC147 subpopulations of Klebsiella pneumoniae harboring blaNDM-1: a comparative genomic analysis of carbapenem resistant strains

Pajand, Omid; Rahimi, Hamzeh; Badmasti, Farzad; Gholami, Faeze; Alipour, Tahereh; Darabi, Narges; Aarestrup, Frank M.; Leekitcharoenphon, Pimlapas

doi:10.1186/s12929-023-00960-0

Journal of Biomedical Science

Table 1 Demographic characteristics of K. pneumoniae subjected to WGS

From: Various arrangements of mobile genetic elements among CC147 subpopulations of Klebsiella pneumoniae harboring bla_NDM-1: a comparative genomic analysis of carbapenem resistant strains

Strain No	ST^a	KL, O-type^b	Ward of isolation	Sample^c	MDR ^d	age	Gender ^e	Yersiniabactin; ICE	IMI, MEM, ETP ^f (μg/ml)
35	14	16, O1v1	Internal ICU	Respiratory	+	85	F	ybt 1-; ICEKp4
56^♦			Internal ICU	UC		68	F		2, 2, 32
361^♦			Internal ICU	UC		68	F		0.5, 1, 2
364^♦			Internal	UC		83	F		0.5, 0.38, 2
607	40	155, OL101	Internal	UC	+	10	F	Negative	1, 1, 32
635			Internal	Respiratory		74	F
691			Surgical ICU	UC		14	F
152^♦	45	52, OL101	Internal ICU	BC	+	54	F	ybt 1-; ICEKp4	6, 6, 32
190^♦			Internal ICU	Respiratory		89	M		0.5, 0.38, 0.75
200^♦			Internal ICU	Respiratory		85	M		1.5, 2, > 32
525^♦			CCU	Respiratory		93	F		2, 1, > 32
531^♦			Internal ICU	Respiratory		79	M		1, 0.75, 16
606^♦	48	2, O1v1	Internal	UC	+	79	M	Negative	1, 1, > 32
639^♦			Internal ICU	Respiratory		83	F	Negative	> 32 to all
689^♦			Internal ICU	Respiratory		82	F	ybt 1-; ICEKp4	0.5, 0.5, 1
693^♦			Internal ICU	Respiratory		80	F	ybt 1-; ICEKp4	4, 4, 32
290	86	2, O1v1	OPD	UC	−	64	F	ybt 9; ICEKp3
533	86	2, O1v1	Emergency	UC	−	64	F	ybt 9; ICEKp3
185*	147	64, O2v1	Surgical ICU	UC	+	80	M	Negative	> 32 to all
500*			Internal ICU	Respiratory		67	F
558*			Internal ICU	UC		90	M
589*			Internal ICU	Respiratory		85	M
640*			Internal ICU	UC		79	F
653*			Surgical ICU	Respiratory		76	M
655*^♦			Internal	UC		54	F
697*			Surgical ICU	UC		72	M
718*			Internal ICU	BC		65	F
254	256	47, OL101	Surgical ICU	BC	−	61	M	Negative
298	348	62, O1v1	OPD	UC	−	90	F	ybt 14; ICEKp5
560^♦	377	102, O2v2	Internal ICU	Respiratory	+	34	M	ybt 16; ICEKp12	> 32 to all
686^♦	377	102, O2v2	Internal ICU	Respiratory	+	54	M	ybt 16; ICEKp12	4, 4, 16
111*	392	27, O4	Surgical ICU	Respiratory	+	33	M	ybt 9; ICEKp3	> 32 to all
117*^♦			Surgical ICU	Respiratory		35	M		> 32 to all
2*			Internal ICU	Respiratory		68	F		6, 16, 32
275*^♦			Internal ICU	UC		83	F		3, 24, 24
432*			Internal ICU	Respiratory		77	F		6, 6, 16
350^♦			Internal ICU	Respiratory		85	M		1.5, 4, 32
351^♦			Internal	Respiratory		76	M		0.5, 0.5, 32
191*^♦			Surgical ICU	UC		49	M		24, 6, 32
247*^♦			Internal ICU	UC		89	M		12, 6, 16
118*^♦			Internal	UC		54	F	Negative	32, 12, 32
434*			Internal ICU	Wound		26	M		6, 6, 8
447*			CCU	UC		63	M		> 32 to all
45^♦			Internal ICU	Wound		82	F		12, 12, 32
460			Surgical ICU	UC		90	M		ND
659*			Internal	UC		89	M		> 32 to all
77^♦			Internal ICU	UC		34	F		4, 4, 32
700	815	107, O4	Internal ICU	UC	−	65	F	Negative
416	1308	144, O4	OPD	UC	+	27	M	Negative
670		144, O4	Internal	UC	+	32	F
671		144, O4	Internal	UC	+	61	M
114	1565	31, OL104	Internal	UC	−	83	M	Negative
542	2159	1, O1v2	Surgical ICU	UC	−	71	F	Negative
22	6510	22, O2v1	Internal	UC	+	85	F	Negative

^♦Indicates carrying bla_OXA-48, *Indicates carrying bla_NDM-1, a: Sequence type; b: capsular type; c: BC & UC stand for blood and Urine culture, respectively; d: Multidrug resistant; e: Female, Male; f: Minimum Inhibitory Concentrations of imipenem, meropenem and ertapenem are determined for some of the study strains

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ISSN: 1423-0127

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