Fig. 6

hPRP/HA promote TMJ repair and regeneration in OA. Histopathological evaluation indicated that hPRP/HA restored TMJ matrix synthesis in OA. A Hematoxylin and eosin (H&E), Alcian blue staining, and immunohistochemical staining for Col-II at 4 weeks (black arrow indicate the presence of Col-II). Representative images (n = 3). Scale bars: 500 or 100 μm. B Percentage areal deposition of proteoglycan by quantification of Alcian-stained area, and C percentages of Col-II cells in TMJ condylar cartilage. D Mankin scores of samples at 4 weeks. E Schematic of the anterior, central, and posterior regions of the rat TMJ condylar head. The condylar height was measured at each region, including co-At: anterior height; co-Ct: central height; and co–Pt: posterior height of condyle. The cartilage thickness was also measured at each region, including C-At: anterior thickness; C-Ct: central thickness; and C-Pt: posterior thickness of cartilage. Measurement of F cartilage thickness and G condylar height at the anterior, posterior, and central regions. *p < 0.05, **p < 0.01,, and ***p < 0.001 and the results are shown as mean ± SD for three replicates