Fig. 9

Therapeutic potential of the combine hPRP/HA treatment in the clinical study. A Schematic of HA and PRP administration into the superior space of TMJ-OA patients. B Disease group without treatment at 0 and 6 months of oblique sagittal MRI images represent disk displacement and osteoarthritis become worse. Quantification of the disc displacement distance from the condyle (C) and condylar thickness were measured at 0 and 6 months (cases 1 and 2, n = 1) (D). In the treatment group (E), patients of disc displacement with reduction (DDR), disc displacement without reduction (DDWR) are designated as case 1, and case 2, respectively, that were associated with disk degeneration, and osteoarthritis of the condyle at 6 months post-treatment. Oblique sagittal MRI images indicated disc recapture and condylar remodeling after using the hPRP/HA treatment compared with the disease or untreated group. In the treatment group disc displacement distance from the condyle (F) and condylar thickness (G) was measured at 0 and 6 months. *p < 0.05, **p < 0.01, and ***p < 0.001 compared with I + T and control group using paired t test