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Fig. 7 | Journal of Biomedical Science

Fig. 7

From: Mitochondrial impairment and synaptic dysfunction are associated with neurological defects in iPSCs-derived cortical neurons of MERRF patients

Fig. 7

Attenuation of evoked potential-stimulated excitability in MERRF neurons harboring the m.8344A > G mutation. A The spike histograms shows the evoked electrical activity of neurons during 5 times of continuous current stimulation in neurons after 10 weeks of differentiation. B A plot represents the number of evoked potential-stimulated spike and evoked first spike latency in MERRF neurons compared to those of N and M3Low neurons. Data are presented as mean ± SEM, n = 3. *p < 0.05; **p < 0.01

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