Fig. 2
From: Induced pluripotent stem cells: ex vivo models for human diseases due to mitochondrial DNA mutations
iPSC models for human diseases due to mtDNA alterations. In modelling mtDNA diseases, patient derived cells are firstly reprogrammed to iPSCs. With mitochondrial base editing and mito-TALEN, the manipulating of mtDNA in iPSCs is achievable. The patient derived iPSCs and genetically corrected iPSCs are differentiated to distinct types of targeting cells to investigate the pathophysiology and to develop the therapeutic intervention approaches for these diseases