Fig. 5

CD73 expression correlated with tumor budding in primary HNSCC. A Tabular depiction of non-budding and budding HNSCC (each n = 10) including CD73 IHC scores [34] in normal mucosa and primary HNSCC, gender, age, adjuvant treatment, T- and N-stage, localization, lymphatic and vascular infiltration, perineural invasion (PNI), and extranodal extension (ENE). B Representative CD73 IHC staining in normal mucosa and HNSCC from non-budding and budding tumors. Two magnifications are depicted with squares marking magnified areas. C Quantification of CD73 IHC scores in normal mucosa and primary tumors (n = 20 each) (left) and in non-budding (negative) and budding HNSCC (positive) (each n = 10). Shown are mean with SD. ** p < 0.01; *** p < 0.001