Fig. 7

CD73 expression with overall survival in large clinical cohorts of HNSCC. A, D, G CD73 and EGFR mRNA expression are shown from bulk RNAseq datasets of HPV-negative HNSCC patients of TCGA (A), the Fred Hutchinson Cancer Research Center (D), and GSE65858 (G) with Spearman correlation r-values and p-values. B, E, H Pearson correlation ρ values of CD73 mRNA expression and EGFR pathway activity, EGFR-EMT, hallmark EMT, pEMT, MAPK and Akt activity GSVA scores across bulk RNAseq datasets of HPV-negative HNSCC patients of TCGA (B), the Fred Hutchinson Cancer Research Center (E), and GSE65858 (H). C, F, I Survival probabilities are depicted in Kaplan–Meier curves for HPV-negative HNSCC patients of TCGA (C; n = 415), the Fred Hutchinson Cancer Research Center (F; n = 97), and GSE65858 (I; n = 196) stratified for the median of CD73 expression with Logrank p-values