Fig. 1

Schematic illustration of the structure, important membrane markers, and cargo of platelets, platelet granules, and platelet extracellular vesicles. ADP adenosine diphosphate, ATP adenosine triphosphate, BDNF brain derived neurotrophic factor, EV extracellular vesicles, GP glycoprotein, HGF hepatocyte growth factor, ICAM intercellular adhesion molecule, JAM-3 junctional adhesion molecule, PF4 platelet factor 4, P-sel P-selectin, PDGF platelet-derived growth factor, PSGL-1 P-selectin glycoprotein ligand-1, RANTES regulated upon activation, normal T-cell expressed and secreted, TGF-B1 transforming growth factor-ß1, TREM triggering receptors expressed on myeloid cells, VEGF vascular endothelium growth factor