Fig. 4
From: Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis
Coordination of mitochondrial biogenesis and mitophagy. PGC-1α is the primary regulator of mitobiogenesis, and in an NRF1-dependent manner, PGC-1α also regulates the expression of the mitophagy receptor Fundc1. The NFE2L2 homolog SKN-1 regulates the expression of the BNIP3/NIX homolog DCT-1 in C. elegans. In addition, PGC-1α activity can be decreased by mitophagy defects by either controlling its stability (Fundc1 deficiency) or suppressing its expression in a Parkin-PARIS-CREB pathway-dependent manner