Table 5 Diagnosis criteria of CAR-T-cell-related HLH/MAS
From: Complete spectrum of adverse events associated with chimeric antigen receptor (CAR)-T cell therapies
Ferritin level | A peak serum ferritin level of > 10,000 ng/ml (during CRS phase) |
|---|---|
AND | |
Clinical and Pathology (any two of the criteria) | Grade ≥ 3 increase in serum bilirubin, aspartate aminotransferase, or alanine aminotransferase levels |
Grade ≥ 3 oliguria or increase in serum creatinine levels | |
Grade ≥ 3 pulmonary edema | |
Presence of haemophagocytosis in bone marrow or organs based on histopathological assessment of cell morphology and/or CD68 immunohistochemistry | |