Butterflies in the gut: the interplay between intestinal microbiota and stress

Lai, Tzu-Ting; Liou, Chia-Wei; Tsai, Yu-Hsuan; Lin, Yuan-Yuan; Wu, Wei-Li

doi:10.1186/s12929-023-00984-6

Journal of Biomedical Science

Table 3 The effect of antibiotics on corticosterone in rodents

From: Butterflies in the gut: the interplay between intestinal microbiota and stress

Molecule	Species	Vendor	Strain	Sex	Diet	Age	Chemicals	Dosage	Route	Timing for antibiotic treatment	Sample	Testing time	Treatment	Detection	Changes	Reference (PMID)
Corticosterone	Mouse	Jackson Laboratory	C57BL/6J	Male	N/A	9 weeks	Bacitracin	0.5 mg/mL	Water	7–9 weeks old	Serum	Afternoon	Baseline	N/A	No change	27752130
							Neomycin	2 mg/mL
							Vancomycin	0.2 mg/mL
							Pimaricin	1.2 µg/mL
		Samtaco Animal Breeding Center	C57BL/6	Male	N/A	6 weeks	Ampicillin	100 mg/kg	Gavage	Once a day for 2 days	Serum	N/A	EPM	120 min	Increase	29867078
		–	C57BL/6	Male	N/A	100 days	Ampicillin	1 mg/mL	Water	21–100 days old	Serum	N/A	Baseline	N/A	No change	34824332
							Vancomycin	5 mg/mL					Aβ1–42	N/A	No change
							Neomycin	10 mg/mL
							Metronidazole	10 mg/mL
							Amphotericin B	0.1 mg/mL
		Jackson Laboratory	C57BL/6	Male	N/A	23 weeks	Ampicillin	1%	Water	4–23 weeks old	Serum	N/A	Baseline (fasting for 5 h)	N/A	No change	34856844
							Neomycin	1%					Social overcrowding (fasting for 5 h)	N/A	Decrease
		Taconic Farms	C57BL/6N	Male		8 weeks	Ampicillin	1 g/L	Water	6–8 weeks old	Serum	N/A	Novel cage for 3 h + Saline	90 min	No change	34401412
							Vancomycin	0.5 g/L					Novel cage for 3 h + Insuline	90 min	No change
							Neomycin	0.5 g/L
							Erythromycin	10 mg/L						N/A
		Jackson Laboratory	C57BL/6J	Male	5053 PicoLab Rodent Diet	8–12 weeks	Ampicillin	1 g/L	Water	8–12 weeks old	Serum	13:00–17:00	Novel cage for 5 min	60 min	No change	34194038
							Vancomycin	0.5 g/L				13:00–17:00	Novel cage + Social interactio for 5 min	60 min	Increase
							Neomycin	1 g/L
							Metronidazole	0.5 g/L
							Sucrose	1%
		Charles River	C57BL/6J	Male	N/A	8–12 weeks	Ampicillin	1 g/L	Water	8–12 weeks old	Plasma	6:00	Baseline	N/A	Increase	23663780
							Vancomycin	0.5 g/L				18:00	Baseline	N/A	Increase
							Neomycin	1 g/L
							Metronidazole	1 g/L
		Sichuan	BALB/c	Male	N/A	17–19 weeks	Ceftriaxone	250 mg/mL, 0.2 mL/d	Gavage	Once a day for 11 weeks	Serum	8:00–5:00	Gavage stress	60 min	Increase	32714875
		N/A	BALB/c	Male	N/A	70 days	Ampicillin	1 mg/mL	Water	21–28, 35–42, 49–56 days old	Serum	N/A	Baseline	N/A	No change	29872772
		N/A	BALB/c	Male	N/A	70 days	Cefoperazone	1 mg/mL	Water	21–28, 35–42, 49–56 days old	Serum	N/A	Baseline	N/A	No change	29872772
		N/A	BALB/c	Male	N/A	70 days	Ampicillin + Cefoperazone	1 mg/mL	Water	21–28, 35–42, 49–56 days old	Serum	N/A	Baseline	N/A	No change	29872772
		Japan SLC	ICR	Male	5% fat, 24% protein, and 54% carbohydrate	P12, 15, 21	Nebacitin [bacitracin-neomycin sulphate 2:1]	7 g/kg	Diet	ED14-21 days old	Plasma	N/A	Baseline	N/A	No change	34170061
		Japan SLC	ICR	Male	5% fat, 24% protein, and 54% carbohydrate	P39	Nebacitin [bacitracin-neomycin sulphate 2:1]	7 g/kg	Diet	ED14-39 days old	Plasma	N/A	Restraint stress for 20 min	0, 20, 60, 120 min	Decrease at 60 min	34170061
		Japan SLC	ICR	Pregnant female	N/A	Adult	Nebacitin [bacitracin-neomycin sulphate 2:1]	7 g/kg	Diet	ED14-21 days old	Plasma	N/A	Baseline	N/A	No change	34170061
		Sichuan	Kunming	N/A	N/A	21 days	Ampicillin	100 mg/kg	Gavage	Once a day (10–21 days old; 10–100 µL)	Serum	N/A	Baseline	N/A	Decrease	32775126
							Vancomycin	50 mg/kg
							Neomycin	100 mg/kg
							Bacitracin	100 mg/kg
							Imipenem	50 mg/kg
							Amphotericin B	1 mg/kg
	Rat	Janvier SA	Wistar	Female	UAR pellets	200–225 g	Neomycin	0.50%	Water	12 days	Plasma	N/A	Baseline	N/A	No change	22541937
							Ampicillin	1%					Partial restraint stress for 2 h	Immediately	Decrease
		CLEA Japan	ODS/Shi Jcl-od/od	Male	AIN93-rodent diet	8 weeks	Neomycin	1 mg/mL	Water	6–8 weeks old	Serum	N/A	Baseline	N/A	No change	32115449
							Vancomycin	0.5 mg/mL					Vitamine C	N/A	No change
							Ampicillin	0.5 mg/mL
		Shanghai Jiesijie	Sprague–Dawley	Male	N/A	200–250 g	Ampicillin	1 g/L	Water	28 days	Serum	N/A	Baseline	N/A	No change	32535221
							Vancomycin	500 mg/L					Intermittent electric shocks + noise for 14 days	Immediately	Decrease
							Neomycin	1 g/L
							Metronidazole	1 g/L
		N/A	Sprague–Dawley	Male	Teklad Global 18% Protein Rodent diet,	23 weeks	Ampicillin	1 g/L	Water	10–16 weeks old	Serum	N/A	Forced swim test	0, 30, 45, 90 min	No change	27742460
					Product code 2018S		Vancomycin	500 mg/L
							Ciprofloxacin HCl	20 mg/L
							Imipenem	250 mg/L
							Metronidazole	1 g/L

N/A: not applicable

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ISSN: 1423-0127

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