Fig. 5

Simplified model illustrating ARID1A’s function in rmodulating MAPK activation through DUSP4 in endometrium-related cancers. The ARID1A protein binds to the regulatory DNA motifs (such as promoters and enhancers) of various genes, including DUSP4. ARID1A sustains active transcriptional histone marks, specifically acetylation. This facilitates an open chromatin state, allowing for the transcription of DUSP4. Notably, DUSP4 serves as a negative regulator of the kinases in the MAPK pathway. When ARID1A is lost, the chromatin transits to a closed state, leading to a decrease in DUSP4 levels and the subsequent activation of the MAPK signaling pathway