Fig. 2From: Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool3D spheroid culture models for the in vitro recreation of the tumor microenvironment. Different culture methods have been adopted to attempt to recreate tissues within in vitro culture conditions. Spherical 3D models have been a golden standard in the field. Depending on cell-source, tissue digestion and culture methods a varying degree of complexity and homology towards native tumor tissues can be achievedBack to article page