Fig. 1

CISD2 expression is down-regulated in sun-exposed sites of the human skin epidermis. A Fluorescent immunohistochemistry (IHC) staining of CISD2 and KRT14 (a marker of the proliferating keratinocytes in the epidermis) in normal human skin. B The icon shows the various collection sites on normal human skin that are present in the human skin tissue array (SKN1001). The sun-exposed sites are marked with an asterisk. C Quantification of CISD2 intensity in the various different sites of human normal skin. D Quantification of KRT14 intensity in various different sites of human normal skin. E Correlation analysis between CISD2 and KRT14 intensity. F CISD2 mRNA expression in the human skin from the suprapubic area (non-sun-exposed) and the lower leg area (sun-exposed). These data were collected from the Human Protein Atlas database (https://www.proteinatlas.org). Data are presented as mean ± SD. *p < 0.05; **p < 0.005. The statistical analysis was performed by Student’s t test