Fig. 6
From: FLT3L-induced virtual memory CD8 T cells engage the immune system against tumors
Schematic summary of this study. In this study, we demonstrated the role of FLT3L in regulating naïve CD8 T cells toward a memory-like phenotype. The FLT3L-induced CD44high naïve CD8 T cells were equipped with virtual memory T cell features and had greater proliferative and effective functions against solid tumors. The underlying mechanism was led through DCs in a type I IFN signaling-dependent manner. Our data provide new insights into FLT3L for the preconditioning of naïve T cells in cancer immunotherapy