Fig. 1

MoDCs infected with GAS strains harboring dysfunctional CovR/S secrete less IL-8 and IL-18. MoDCs were infected with four strains possessing functional CovR/S (5448, 5626, 2006, 8157) or four strains possessing non-functional CovR/S (5448AP, 2002, 5005, 8003) as assessed by sequence analyses and SpeB proteolytic assay. The concentrations of IL-1β (A), IL-18 (B), and IL-8 (C) were measured in supernatants of (un)infected moDCs. Each dot represents one independent experiment with cells from one donor (n ≥ 8). Horizontal lines denote median values. The level of significance was determined using Kruskal–Wallis test with Dunn’s post test. Different shades of color represent infections with different strains