Fig. 5

5448AP-infected moDCs exhibit high caspase-8 activity. MoDCs were infected with 5448 or 5448AP. Relative abundance of caspase-8 (A) and caspase-3 (B) 6 h and 24 h post infection. Original calculations are displayed in Additional file 1: Table S4. C Caspase-8 activity of (un)infected moDCs as measured at indicated time points by luminescence. D Relative caspase-8 activity at 8 h post infection. E Frequencies of caspase-3⁺ moDCs 8 h post infection. Each dot represents one independent experiment with cells from one donor (n ≥ 8). Horizontal lines in (A, B) denote median values. Bars in (D, E) denote mean values. The level of significance was determined using Kruskal–Wallis test with Dunn’s posttest in (A, B, E) or Mann–Whitney U-test in (D). LFQ, label-free quantification intensities; RLU, relative light units