From: Dengue virus pathogenesis and host molecular machineries
Molecular Processes | Viral proteins /UTRs | Host proteins /Components | Function | References |
---|---|---|---|---|
Epigenetics | Â | HDAC | Condense chromatin and slow down host transcription | [28] |
 | CNG7, CCR10, MARF-AS1, CTBP-AS | Localize in cytoplasm to enhance viral replication, proviral effect | ||
NS1 | DIDO1 | NS1 and DIDO1 interaction upregulates viral replication | [35] | |
Capsid | H2A, H2B, H3, H4 | Capsid colocalize core histones to enhance viral replication | [36] | |
Transcription | Envelope | TAL-1 | Hinder host transcription processes | [37] |
 | GATA-1, GATA-2, NF-E2 | Affects the process of Megakaryopoiesis and decrease platelets production | [38] | |
 | CDK8 | Upregulates the glycolysis and metabolic enzyme production. Proviral effect | [39] | |
DENV core protein | P-TEFb | Regulates DENV Pathogenesis | [40] | |
Post-transcriptional | NS5 | snRNPs | Alters the process of splicing | [41] |
NS5 | RBM10 | Generate proviral isoforms via alternative splicing | [42] | |
sfRNA | XRN1 | Inhibit exonuclease activity and stabilize viral RNA | [43] | |
NS3 and NS4A | IRAV and MOV10 | Antiviral activity | [44] | |
Translation |  | eIF4E | Recognize 5’ Cap of viral RNA | [45] |
sfRNA | G3BP1, G3BP2, Caprin1 | Inhibition of interferon stimulated gene (ISG) translation | [46] | |
3’ UTR | PABP | Regulates translation of DENV RNA | [47] | |
Post-translational | NS3 | TRIM69 | TRIM69 targets NS3 for protesosomal degradation | [48] |
Envelope | Â | Envelope glycosylation helps to attach with host receptors for viral entry, proviral effect | ||
NS1 | C1s, C4, MBL | Glycosylated NS1 interacts with C1s, C4, MBL inhibits interferon related response, showing proviral effect | [52] | |
NS5 | STAT2 | Target proteosomal degradation, antiviral effect | [53] | |
 | STAT3 | Negatively regulate Type I IFN and Type III interferon responses and enhance viral propagation | [54] | |
Stress Responses | NS3 | TIA1, TIAR | Colocalize to enhance viral propagation | [55] |
3’UTR | G3BP1, G3BP2, DDX6, Caprin1, USP10 | Colocalize to enhance viral propagation | [56] | |
NS4B | VCP1-NPL4 | Proviral effect | [57] | |
NS1 | ATF3 | Contributes to neuroinflammation during dengue infection | [58] |