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Table 2 Various anti-DENV therapeutics in development

From: Dengue virus pathogenesis and host molecular machineries

Target Proteins (DENV)

Compounds/ Inhibitors

References

NS1

Peptide 3, Peptide 4, Peptide 10, and Peptide 11

[129]

NS3 Helicase

Ivermectin, ST-610, Suramin

[140,141,142]

NS2B-NS3 Protease

Protegrin-1, Retrocyclin-1, Nelfinavir, Carnosine, Palmatine, Thiazolidinone-peptide hybrids, Compound 32, Compound 1, 166347, ARDP0006, ARDP0009, Compound 7n, Diaryl(thio)ethers, Compound C, and Compound D

[134,135,136,137]

NS4B

JNJ-1802, JNJ-A07, NITD 618, SDM25N, AM404, and NITD-688

[122,123,124,125,126, 128]

Envelope

1662G07, DN59, NITD488, and Geraniin

[130,131,132,133]

Membrane

MLH40

[143]

Capsid

VGTI-A3, VGTI-A3-03, ST-148

[138, 139]