Fig. 7
From: Targeting NLRP3 signaling reduces myocarditis-induced arrhythmogenesis and cardiac remodeling
Potential mechanisms underlying the role of NLRP3 signaling in myocarditis. MCC950 treatment may reverse myocarditis-induced Na+–Ca2+ dysregulation by mitigating the alterations in levels of ROS, CMKII, RyR2, and ionic channels in cardiomyocytes. INa-Late: late Na+ current; NCX, Na+–Ca2+ exchanger; ROS, reactive oxygen species; RyR2, ryanodine receptor 2; RyR2-pS2808, RyR2 phosphorylated at serine 2808; SR, sarcoplasmic reticulum; SERCA, sarcoplasmic reticulum ATPase