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  1. Research

    Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese

    Alcohol consumption and oxidative stress are well-known risk factors for developing atrial fibrillation (AF). Single nucleotide polymorphisms (SNPs) of alcohol dehydrogenase (ADH1B) and aldehyde dehydrogenase 2 (

    Yukiko Nakano, Hidenori Ochi, Yuko Onohara, Akinori Sairaku, Takehito Tokuyama, Hiroya Matsumura, Shunsuke Tomomori, Michitaka Amioka, Naoya Hironomobe, Chikaaki Motoda, Nozomu Oda, Kazuaki Chayama, Che-Hong Chen, Eric R. Gross, Daria Mochly-Rosen and Yasuki Kihara

    Journal of Biomedical Science 2016 23:89

    Published on: 7 December 2016

  2. Review

    The paradox role of caspase cascade in ionizing radiation therapy

    Radiotherapy alone or in combination with chemotherapy/surgery is widely used for treatment of cancers. It reduces tumor growth and prevents metastasis. While ionizing radiation activates caspase cascade resul...

    Najmeh Rahmanian, Seyed Jalal Hosseinimehr and Ali Khalaj

    Journal of Biomedical Science 2016 23:88

    Published on: 7 December 2016

  3. Review

    Update on recent preclinical and clinical studies of T790M mutant-specific irreversible epidermal growth factor receptor tyrosine kinase inhibitors

    The first- and second-generation epidermal growth factor receptor tyrosine kinase inhibitors (1/2G EGFR-TKIs) gefitinib, erlotinib, and afatinib have all been approved as standard first-line treatments for adv...

    Bin-Chi Liao, Chia-Chi Lin, Jih-Hsiang Lee and James Chih-Hsin Yang

    Journal of Biomedical Science 2016 23:86

    Published on: 3 December 2016

  4. Research

    Differential humoral and cellular immunity induced by vaccination using plasmid DNA and protein recombinant expressing the NS3 protein of dengue virus type 3

    The dengue non-structural 3 (NS3) is a multifunctional protein, containing a serine-protease domain, located at the N-terminal portion, and helicase, NTPase and RTPase domains present in the C-terminal region....

    M. L. Hurtado-Melgoza, A. Ramos-Ligonio, L. M. Álvarez-Rodríguez, T. Meza-Menchaca and A. López-Monteon

    Journal of Biomedical Science 2016 23:85

    Published on: 1 December 2016

  5. Research

    Suberoylanilide hydroxamic acid represses glioma stem-like cells

    Glioma stem-like cells (GSCs) are proposed to be responsible for high resistance in glioblastoma multiforme (GBM) treatment. In order to find new strategies aimed at reducing GSC stemness and improving GBM pat...

    Che-Chia Hsu, Wen-Chang Chang, Tsung-I Hsu, Jr-Jiun Liu, Shiu-Hwa Yeh, Jia-Yi Wang, Jing-Ping Liou, Chiung-Yuan Ko, Kwang-Yu Chang and Jian-Ying Chuang

    Journal of Biomedical Science 2016 23:81

    Published on: 18 November 2016

  6. Research

    Defective autophagy leads to the suppression of stem-like features of CD271+ osteosarcoma cells

    As an important stress-response mechanism, autophagy plays crucial role in the tumor formation and drug resistance of cancer cells including osteosarcoma (OS). OS cancer stem cells (CSCs) also are considered a...

    Dong Zhang, Qing Zhao, Hao Sun, Lijuan Yin, Jiajun Wu, Jun Xu, Tianxiang He, Chunlei Yang and Chengwei Liang

    Journal of Biomedical Science 2016 23:82

    Published on: 18 November 2016

  7. Review

    Developing precision medicine for people of East Asian descent

    The goal of precision medicine is to separate patient populations into groups to ultimately provide customized care tailored to patients. In terms of precision medicine, ~540 million people in the world have a...

    Stacy L. McAllister, Katherine Sun and Eric R. Gross

    Journal of Biomedical Science 2016 23:80

    Published on: 11 November 2016

  8. Research

    miR-199a-3p inhibits cell proliferation and induces apoptosis by targeting YAP1, suppressing Jagged1-Notch signaling in human hepatocellular carcinoma

    miR-199a-3p was significantly downregulated in the majority of human hepatocellular carcinoma (HCC) tissues and HCC cell lines. Yes associated protein 1 (YAP1) was overexpressed in human HCC, which promoted HC...

    Kewei Ren, Tengfei Li, Wenzhe Zhang, Jianzhuang Ren, Zhen Li and Gang Wu

    Journal of Biomedical Science 2016 23:79

    Published on: 10 November 2016

  9. Research

    Calcitriol stimulates gene expression of cathelicidin antimicrobial peptide in breast cancer cells with different phenotype

    In normal and neoplastic cells, growth-promoting, proangiogenic, cytotoxic and pro-apoptotic effects have all been attributed to cathelicidin antimicrobial peptide (CAMP). Nevertheless, little is known about the ...

    Janice García-Quiroz, Rocío García-Becerra, Nancy Santos-Martínez, Euclides Avila, Fernando Larrea and Lorenza Díaz

    Journal of Biomedical Science 2016 23:78

    Published on: 10 November 2016

  10. Review

    Biomimetic approaches with smart interfaces for bone regeneration

    A ‘smart tissue interface’ is a host tissue-biomaterial interface capable of triggering favourable biochemical events inspired by stimuli responsive mechanisms. In other words, biomaterial surface is instrumental...

    G. S. Sailaja, P. Ramesh, Sajith Vellappally, Sukumaran Anil and H. K. Varma

    Journal of Biomedical Science 2016 23:77

    Published on: 5 November 2016

  11. Review

    Perspectives for therapeutic HPV vaccine development

    Human papillomavirus (HPV) infections and associated diseases remain a serious burden worldwide. It is now clear that HPV serves as the etiological factor and biologic carcinogen for HPV-associated lesions and...

    Andrew Yang, Emily Farmer, T. C. Wu and Chien-Fu Hung

    Journal of Biomedical Science 2016 23:75

    Published on: 4 November 2016

  12. Review

    Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials

    Human mesenchymal stem cells (MSCs) are multilineage somatic progenitor/stem cells that have been shown to possess immunomodulatory properties in recent years. Initially met with much skepticism, MSC immunomod...

    Li-Tzu Wang, Chiao-Hsuan Ting, Men-Luh Yen, Ko-Jiunn Liu, Huey-Kang Sytwu, Kenneth K. Wu and B. Linju Yen

    Journal of Biomedical Science 2016 23:76

    Published on: 4 November 2016

  13. Research

    Therapeutic effect of berberine on TDP-43-related pathogenesis in FTLD and ALS

    In the central nervous system regions of the sporadic and familial FTLD and ALS patients, TDP-43 has been identified as the major component of UBIs inclusions which is abnormally hyperphosphorylated, ubiquitin...

    Cheng-Fu Chang, Yi-Chao Lee, Kuen-Haur Lee, Hui-Ching Lin, Chia-Ling Chen, Che-Kun James Shen and Chi-Chen Huang

    Journal of Biomedical Science 2016 23:72

    Published on: 21 October 2016

  14. Research

    RNA binding protein Nova1 promotes tumor growth in vivo and its potential mechanism as an oncogene may due to its interaction with GABAA Receptor-γ2

    The mechanism of Nova1’s role in hepatocellular carcinoma has not been delineated. Also its interaction with GABAA receptor γ2 in HCC is unveiled. This study is aimed to make it clear the distribution, prognostic...

    Yi-An Zhang, Hai-Ning Liu, Ji-Min Zhu, Dan-Ying Zhang, Xi-Zhong Shen and Tao-Tao Liu

    Journal of Biomedical Science 2016 23:71

    Published on: 12 October 2016

  15. Review

    Rab-mediated vesicle trafficking in cancer

    A large group of small Rab GTPases which mediate secretory and endosomal membrane transport, as well as autophagosome biogenesis, are essential components of vesicle trafficking machinery. Specific Rab protein...

    Hong-Tai Tzeng and Yi-Ching Wang

    Journal of Biomedical Science 2016 23:70

    Published on: 6 October 2016

  16. Research

    Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes gluconeogenesis by modulating the PI3K/Akt pathway in the liver

    Glycine N-methyltransferase (GNMT) is abundantly expressed in the normal liver but is down-regulated in liver cancer tissues. GNMT knockout (Gnmt−/−) mice can spontaneously develop chronic hepatitis, fatty liv...

    Yi-Jen Liao, Tzong-Shyuan Lee, Yuh-Ching Twu, Shih-Ming Hsu, Ching-Ping Yang, Chung-Kwe Wang, Yu-Chih Liang and Yi-Ming Arthur Chen

    Journal of Biomedical Science 2016 23:69

    Published on: 4 October 2016

  17. Review

    Phage display as a promising approach for vaccine development

    Bacteriophages are specific antagonists to bacterial hosts. These viral entities have attracted growing interest as optimal vaccine delivery vehicles. Phages are well-matched for vaccine design due to being hi...

    Leili Aghebati-Maleki, Babak Bakhshinejad, Behzad Baradaran, Morteza Motallebnezhad, Ali Aghebati-Maleki, Hamid Nickho, Mehdi Yousefi and Jafar Majidi

    Journal of Biomedical Science 2016 23:66

    Published on: 29 September 2016

  18. Research

    Sumoylation of IkB attenuates NF-kB-induced nitrosative stress at rostral ventrolateral medulla and cardiovascular depression in experimental brain death

    Small ubiquitin-related modifier (SUMO) is a group of proteins that participates in post-translational modifications. One known SUMO target is the transcription factor nuclear factor-kB (NF-kB) that plays a pi...

    Ching-Yi Tsai, Faith C. H. Li, Carol H. Y. Wu, Alice Y. W. Chang and Samuel H. H. Chan

    Journal of Biomedical Science 2016 23:65

    Published on: 22 September 2016

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Journal of Biomedical Science is supported by the Ministry of Science and Technology (MOST), Taiwan.

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