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  1. Review

    Developing precision medicine for people of East Asian descent

    The goal of precision medicine is to separate patient populations into groups to ultimately provide customized care tailored to patients. In terms of precision medicine, ~540 million people in the world have a...

    Stacy L. McAllister, Katherine Sun and Eric R. Gross

    Journal of Biomedical Science 2016 23:80

    Published on: 11 November 2016

  2. Research

    miR-199a-3p inhibits cell proliferation and induces apoptosis by targeting YAP1, suppressing Jagged1-Notch signaling in human hepatocellular carcinoma

    miR-199a-3p was significantly downregulated in the majority of human hepatocellular carcinoma (HCC) tissues and HCC cell lines. Yes associated protein 1 (YAP1) was overexpressed in human HCC, which promoted HC...

    Kewei Ren, Tengfei Li, Wenzhe Zhang, Jianzhuang Ren, Zhen Li and Gang Wu

    Journal of Biomedical Science 2016 23:79

    Published on: 10 November 2016

  3. Research

    Calcitriol stimulates gene expression of cathelicidin antimicrobial peptide in breast cancer cells with different phenotype

    In normal and neoplastic cells, growth-promoting, proangiogenic, cytotoxic and pro-apoptotic effects have all been attributed to cathelicidin antimicrobial peptide (CAMP). Nevertheless, little is known about the ...

    Janice García-Quiroz, Rocío García-Becerra, Nancy Santos-Martínez, Euclides Avila, Fernando Larrea and Lorenza Díaz

    Journal of Biomedical Science 2016 23:78

    Published on: 10 November 2016

  4. Review

    Biomimetic approaches with smart interfaces for bone regeneration

    A ‘smart tissue interface’ is a host tissue-biomaterial interface capable of triggering favourable biochemical events inspired by stimuli responsive mechanisms. In other words, biomaterial surface is instrumental...

    G. S. Sailaja, P. Ramesh, Sajith Vellappally, Sukumaran Anil and H. K. Varma

    Journal of Biomedical Science 2016 23:77

    Published on: 5 November 2016

  5. Review

    Perspectives for therapeutic HPV vaccine development

    Human papillomavirus (HPV) infections and associated diseases remain a serious burden worldwide. It is now clear that HPV serves as the etiological factor and biologic carcinogen for HPV-associated lesions and...

    Andrew Yang, Emily Farmer, T. C. Wu and Chien-Fu Hung

    Journal of Biomedical Science 2016 23:75

    Published on: 4 November 2016

  6. Review

    Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials

    Human mesenchymal stem cells (MSCs) are multilineage somatic progenitor/stem cells that have been shown to possess immunomodulatory properties in recent years. Initially met with much skepticism, MSC immunomod...

    Li-Tzu Wang, Chiao-Hsuan Ting, Men-Luh Yen, Ko-Jiunn Liu, Huey-Kang Sytwu, Kenneth K. Wu and B. Linju Yen

    Journal of Biomedical Science 2016 23:76

    Published on: 4 November 2016

  7. Research

    Therapeutic effect of berberine on TDP-43-related pathogenesis in FTLD and ALS

    In the central nervous system regions of the sporadic and familial FTLD and ALS patients, TDP-43 has been identified as the major component of UBIs inclusions which is abnormally hyperphosphorylated, ubiquitin...

    Cheng-Fu Chang, Yi-Chao Lee, Kuen-Haur Lee, Hui-Ching Lin, Chia-Ling Chen, Che-Kun James Shen and Chi-Chen Huang

    Journal of Biomedical Science 2016 23:72

    Published on: 21 October 2016

  8. Research

    RNA binding protein Nova1 promotes tumor growth in vivo and its potential mechanism as an oncogene may due to its interaction with GABAA Receptor-γ2

    The mechanism of Nova1’s role in hepatocellular carcinoma has not been delineated. Also its interaction with GABAA receptor γ2 in HCC is unveiled. This study is aimed to make it clear the distribution, prognostic...

    Yi-An Zhang, Hai-Ning Liu, Ji-Min Zhu, Dan-Ying Zhang, Xi-Zhong Shen and Tao-Tao Liu

    Journal of Biomedical Science 2016 23:71

    Published on: 12 October 2016

  9. Review

    Rab-mediated vesicle trafficking in cancer

    A large group of small Rab GTPases which mediate secretory and endosomal membrane transport, as well as autophagosome biogenesis, are essential components of vesicle trafficking machinery. Specific Rab protein...

    Hong-Tai Tzeng and Yi-Ching Wang

    Journal of Biomedical Science 2016 23:70

    Published on: 6 October 2016

  10. Research

    Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes gluconeogenesis by modulating the PI3K/Akt pathway in the liver

    Glycine N-methyltransferase (GNMT) is abundantly expressed in the normal liver but is down-regulated in liver cancer tissues. GNMT knockout (Gnmt−/−) mice can spontaneously develop chronic hepatitis, fatty liv...

    Yi-Jen Liao, Tzong-Shyuan Lee, Yuh-Ching Twu, Shih-Ming Hsu, Ching-Ping Yang, Chung-Kwe Wang, Yu-Chih Liang and Yi-Ming Arthur Chen

    Journal of Biomedical Science 2016 23:69

    Published on: 4 October 2016

  11. Review

    Phage display as a promising approach for vaccine development

    Bacteriophages are specific antagonists to bacterial hosts. These viral entities have attracted growing interest as optimal vaccine delivery vehicles. Phages are well-matched for vaccine design due to being hi...

    Leili Aghebati-Maleki, Babak Bakhshinejad, Behzad Baradaran, Morteza Motallebnezhad, Ali Aghebati-Maleki, Hamid Nickho, Mehdi Yousefi and Jafar Majidi

    Journal of Biomedical Science 2016 23:66

    Published on: 29 September 2016

  12. Research

    Sumoylation of IkB attenuates NF-kB-induced nitrosative stress at rostral ventrolateral medulla and cardiovascular depression in experimental brain death

    Small ubiquitin-related modifier (SUMO) is a group of proteins that participates in post-translational modifications. One known SUMO target is the transcription factor nuclear factor-kB (NF-kB) that plays a pi...

    Ching-Yi Tsai, Faith C. H. Li, Carol H. Y. Wu, Alice Y. W. Chang and Samuel H. H. Chan

    Journal of Biomedical Science 2016 23:65

    Published on: 22 September 2016

  13. Research

    A phase I clinical study of immunotherapy for advanced colorectal cancers using carcinoembryonic antigen-pulsed dendritic cells mixed with tetanus toxoid and subsequent IL-2 treatment

    To better evaluate and improve the efficacy of dendritic cell (DC)-based cancer immunotherapy, we conducted a clinical study of patients with advanced colorectal cancer using carcinoembryonic antigen (CEA)-pul...

    Ko-Jiunn Liu, Tsu-Yi Chao, Jang-Yang Chang, Ann-Lii Cheng, Hui-Ju Ch’ang, Woei-Yau Kao, Yu-Chen Wu, Wei-Lan Yu, Tsai-Rong Chung and Jacqueline Whang-Peng

    Journal of Biomedical Science 2016 23:64

    Published on: 24 August 2016

  14. Review

    Role of vasoactive intestinal peptide in osteoarthritis

    Vasoactive intestinal peptide (VIP) plays important roles in many biological functions, such as, stimulation of contractility in the heart, vasodilation, promoting neuroendocrine-immune communication, lowering...

    Wei Jiang, Hua Wang, Yu-sheng Li and Wei Luo

    Journal of Biomedical Science 2016 23:63

    Published on: 23 August 2016

  15. Review

    Hypoxia and its implications in rheumatoid arthritis

    Alterations in tissue oxygen pressure contribute to a number of diseases, including rheumatoid arthritis (RA). Low partial pressure of oxygen, a condition known as hypoxia, is a relevant feature in RA since it...

    Celia María Quiñonez-Flores, Susana Aideé González-Chávez and César Pacheco-Tena

    Journal of Biomedical Science 2016 23:62

    Published on: 22 August 2016

  16. Review

    WSB1: from homeostasis to hypoxia

    The wsb1 gene has been identified to be important in developmental biology and cancer. A complex transcriptional regulation of wsb1 yields at least three functional transcripts. The major expressed isoform, WSB1 ...

    Moinul Haque, Joseph Keith Kendal, Ryan Matthew MacIsaac and Douglas James Demetrick

    Journal of Biomedical Science 2016 23:61

    Published on: 19 August 2016

  17. Research

    CSC-3436 switched tamoxifen-induced autophagy to apoptosis through the inhibition of AMPK/mTOR pathway

    Triple-negative breast cancer (TNBC) lacks specific therapeutic target and limits to chemotherapy and is essential to develop novel therapeutic regimens. Increasing studies indicated that tamoxifen, a selectiv...

    Sheng-Tang Wu, Guang-Huan Sun, Tai-Lung Cha, Chien-Chang Kao, Sun-Yran Chang, Sheng-Chu Kuo and Tzong-Der Way

    Journal of Biomedical Science 2016 23:60

    Published on: 15 August 2016

  18. Research

    Motor neuron-derived Thsd7a is essential for zebrafish vascular development via the Notch-dll4 signaling pathway

    Development of neural and vascular systems displays astonishing similarities among vertebrates. This parallelism is under a precise control of complex guidance signals and neurovascular interactions. Previousl...

    Lawrence Yu-Min Liu, Min-Hsuan Lin, Zih-Yin Lai, Jie-Peng Jiang, Yi-Ching Huang, Li-En Jao and Yung-Jen Chuang

    Journal of Biomedical Science 2016 23:59

    Published on: 2 August 2016

  19. Research

    A prognostic predictor panel with DNA methylation biomarkers for early-stage lung adenocarcinoma in Asian and Caucasian populations

    The incidence of lung adenocarcinoma (LUAD) is increasing worldwide with different prognosis even in early-stage patients. We aimed to identify a prognostic panel with multiple DNA methylation biomarkers to pr...

    I-Ying Kuo, Jayu Jen, Lien-Huei Hsu, Han-Shui Hsu, Wu-Wei Lai and Yi-Ching Wang

    Journal of Biomedical Science 2016 23:58

    Published on: 2 August 2016

  20. Research

    Vitamin D3/VDR resists diet-induced obesity by modulating UCP3 expression in muscles

    The impact of vitamin D3 (VD3) on obesity has been reported in the past. Our study was aimed at investigating the possible mechanisms by which VD3 affects obesity induced by a high fat diet.

    Yue Fan, Kumi Futawaka, Rie Koyama, Yuki Fukuda, Misa Hayashi, Miyuki Imamoto, Takashi Miyawaki, Masato Kasahara, Tetsuya Tagami and Kenji Moriyama

    Journal of Biomedical Science 2016 23:56

    Published on: 29 July 2016

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Journal of Biomedical Science is supported by the Ministry of Science and Technology (MOST), Taiwan.