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  1. Review

    State of the art in anti-cancer mAbs

    Following Milstein’s discovery, the monoclonal antibodies (mAbs) became a basic tool for biomedical science. In cancer field, since the first mAb was approved by the FDA a great improvement took place making o...

    S. M. Chiavenna, J. P. Jaworski and A. Vendrell

    Journal of Biomedical Science 2017 24:15

    Published on: 20 February 2017

  2. Review

    Neuroblastoma treatment in the post-genomic era

    Neuroblastoma is an embryonic malignancy of early childhood originating from neural crest cells and showing heterogeneous biological, morphological, genetic and clinical characteristics. The correct stratifica...

    Maria Rosaria Esposito, Sanja Aveic, Anke Seydel and Gian Paolo Tonini

    Journal of Biomedical Science 2017 24:14

    Published on: 8 February 2017

  3. Review

    Macrophage activation and polarization in post-infarction cardiac remodeling

    Adverse cardiac remodeling leads to impaired ventricular function and heart failure, remaining a major cause of mortality and morbidity in patients with acute myocardial infarction. It have been shown that, ev...

    Aleksandra Gombozhapova, Yuliya Rogovskaya, Vladimir Shurupov, Mariya Rebenkova, Julia Kzhyshkowska, Sergey V. Popov, Rostislav S. Karpov and Vyacheslav Ryabov

    Journal of Biomedical Science 2017 24:13

    Published on: 7 February 2017

  4. Research

    Oxidized LDL-induced JAB1 influences NF-κB independent inflammatory signaling in human macrophages during foam cell formation

    Oxidized low-density lipoprotein (oxLDL) mediates the transformation of macrophages (MΦ) to cholesterol-rich foam cells and the release of pro-inflammatory cytokines during atherogenesis. JAB1 (Jun activation ...

    Anja Schwarz, Gabriel A. Bonaterra, Hans Schwarzbach and Ralf Kinscherf

    Journal of Biomedical Science 2017 24:12

    Published on: 7 February 2017

  5. Review

    Escape from IFN-γ-dependent immunosurveillance in tumorigenesis

    Immune interferon (IFN), also known as IFN-γ, promotes not only immunomodulation but also antimicrobial and anticancer activity. After IFN-γ binds to the complex of IFN-γ receptor (IFNGR) 1-IFNGR2 and subseque...

    Chiou-Feng Lin, Chih-Ming Lin, Kang-Yun Lee, Szu-Yuan Wu, Po-Hao Feng, Kuan-Yuan Chen, Hsiao-Chi Chuang, Chia-Ling Chen, Yu-Chih Wang, Po-Chun Tseng and Tsung-Ting Tsai

    Journal of Biomedical Science 2017 24:10

    Published on: 1 February 2017

  6. Review

    Current use of autologous adipose tissue-derived stromal vascular fraction cells for orthopedic applications

    Autologous adipose stromal vascular fractions (SVFs) containing adipose tissue-derived stem cells (ASCs) are currently being used in clinical settings for various orthopedic applications for human patients. Du...

    Jaewoo Pak, Jung Hun Lee, Kwang Seung Park, Moonhee Park, Lin-Woo Kang and Sang Hee Lee

    Journal of Biomedical Science 2017 24:9

    Published on: 31 January 2017

  7. Review

    Harnessing the early post-injury inflammatory responses for cardiac regeneration

    Cardiac inflammation is considered by many as the main driving force in prolonging the pathological condition in the heart after myocardial infarction. Immediately after cardiac ischemic injury, neutrophils ar...

    Bill Cheng, H. C. Chen, I. W. Chou, Tony W. H. Tang and Patrick C. H. Hsieh

    Journal of Biomedical Science 2017 24:7

    Published on: 13 January 2017

  8. Research

    Aberrant methylation of DACT1 and DACT2 are associated with tumor progression and poor prognosis in esophageal squamous cell carcinoma

    The DACT (Dishevelled-associated antagonist of β-catenin) family of scaffold proteins may play important roles in tumorigenesis. However, the epigenetic changes of DACT1, 2, 3 and their effect on esophageal squam...

    Yan-li Guo, Bao-En Shan, Wei Guo, Zhi-Ming Dong, Zhen Zhou, Su-Peng Shen, Xin Guo, Jia Liang and Gang Kuang

    Journal of Biomedical Science 2017 24:6

    Published on: 11 January 2017

  9. Review

    PPARs modulate cardiac metabolism and mitochondrial function in diabetes

    Diabetic cardiomyopathy is a major complication of diabetes mellitus (DM). Currently, effective treatments for diabetic cardiomyopathy are limited. The pathophysiology of diabetic cardiomyopathy is complex, wh...

    Ting-Wei Lee, Kuan-Jen Bai, Ting-I Lee, Tze-Fan Chao, Yu-Hsun Kao and Yi-Jen Chen

    Journal of Biomedical Science 2017 24:5

    Published on: 10 January 2017

  10. Research

    Inhibition of Epstein-Barr virus reactivation by the flavonoid apigenin

    Lytic reactivation of EBV has been reported to play an important role in human diseases, including NPC carcinogenesis. Inhibition of EBV reactivation is considered to be of great benefit in the treatment of vi...

    Chung-Chun Wu, Chih-Yeu Fang, Yu-Jhen Cheng, Hui-Yu Hsu, Sheng-Ping Chou, Sheng-Yen Huang, Ching-Hwa Tsai and Jen-Yang Chen

    Journal of Biomedical Science 2017 24:2

    Published on: 5 January 2017

  11. Research

    Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese

    Alcohol consumption and oxidative stress are well-known risk factors for developing atrial fibrillation (AF). Single nucleotide polymorphisms (SNPs) of alcohol dehydrogenase (ADH1B) and aldehyde dehydrogenase 2 (

    Yukiko Nakano, Hidenori Ochi, Yuko Onohara, Akinori Sairaku, Takehito Tokuyama, Hiroya Matsumura, Shunsuke Tomomori, Michitaka Amioka, Naoya Hironomobe, Chikaaki Motoda, Nozomu Oda, Kazuaki Chayama, Che-Hong Chen, Eric R. Gross, Daria Mochly-Rosen and Yasuki Kihara

    Journal of Biomedical Science 2016 23:89

    Published on: 7 December 2016

  12. Review

    The paradox role of caspase cascade in ionizing radiation therapy

    Radiotherapy alone or in combination with chemotherapy/surgery is widely used for treatment of cancers. It reduces tumor growth and prevents metastasis. While ionizing radiation activates caspase cascade resul...

    Najmeh Rahmanian, Seyed Jalal Hosseinimehr and Ali Khalaj

    Journal of Biomedical Science 2016 23:88

    Published on: 7 December 2016

  13. Review

    Update on recent preclinical and clinical studies of T790M mutant-specific irreversible epidermal growth factor receptor tyrosine kinase inhibitors

    The first- and second-generation epidermal growth factor receptor tyrosine kinase inhibitors (1/2G EGFR-TKIs) gefitinib, erlotinib, and afatinib have all been approved as standard first-line treatments for adv...

    Bin-Chi Liao, Chia-Chi Lin, Jih-Hsiang Lee and James Chih-Hsin Yang

    Journal of Biomedical Science 2016 23:86

    Published on: 3 December 2016

  14. Research

    Differential humoral and cellular immunity induced by vaccination using plasmid DNA and protein recombinant expressing the NS3 protein of dengue virus type 3

    The dengue non-structural 3 (NS3) is a multifunctional protein, containing a serine-protease domain, located at the N-terminal portion, and helicase, NTPase and RTPase domains present in the C-terminal region....

    M. L. Hurtado-Melgoza, A. Ramos-Ligonio, L. M. Álvarez-Rodríguez, T. Meza-Menchaca and A. López-Monteon

    Journal of Biomedical Science 2016 23:85

    Published on: 1 December 2016

  15. Research

    Suberoylanilide hydroxamic acid represses glioma stem-like cells

    Glioma stem-like cells (GSCs) are proposed to be responsible for high resistance in glioblastoma multiforme (GBM) treatment. In order to find new strategies aimed at reducing GSC stemness and improving GBM pat...

    Che-Chia Hsu, Wen-Chang Chang, Tsung-I Hsu, Jr-Jiun Liu, Shiu-Hwa Yeh, Jia-Yi Wang, Jing-Ping Liou, Chiung-Yuan Ko, Kwang-Yu Chang and Jian-Ying Chuang

    Journal of Biomedical Science 2016 23:81

    Published on: 18 November 2016

  16. Research

    Defective autophagy leads to the suppression of stem-like features of CD271+ osteosarcoma cells

    As an important stress-response mechanism, autophagy plays crucial role in the tumor formation and drug resistance of cancer cells including osteosarcoma (OS). OS cancer stem cells (CSCs) also are considered a...

    Dong Zhang, Qing Zhao, Hao Sun, Lijuan Yin, Jiajun Wu, Jun Xu, Tianxiang He, Chunlei Yang and Chengwei Liang

    Journal of Biomedical Science 2016 23:82

    Published on: 18 November 2016

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Journal of Biomedical Science is supported by the Ministry of Science and Technology (MOST), Taiwan.