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  1. Cholangiocarcinoma represents the second most common primary liver malignancy. The incidence rate has constantly increased over the last decades. Cholangiocarcinoma silent nature limits early diagnosis and pre...

    Authors: Weiqian Chen, Jingjing Song, Siyu Liu, Bufu Tang, Lin Shen, Jinyu Zhu, Shiji Fang, Fazong Wu, Liyun Zheng, Rongfang Qiu, Chunmiao Chen, Yang Gao, Jianfei Tu, Zhongwei Zhao and Jiansong Ji
    Citation: Journal of Biomedical Science 2021 28:44
    Content type: Research Published on:

  2. Coronavirus disease 19 (COVID-19) first appeared in the city of Wuhan, in the Hubei province of China. Since its emergence, the COVID-19-causing virus, SARS-CoV-2, has been rapidly transmitted around the globe...

    Authors: Jing-You Guo, I-Ju Liu, Hsiu-Ting Lin, Mei-Jung Wang, Yu-Ling Chang, Shin-Chang Lin, Mei-Ying Liao, Wei-Chia Hsu, Yi-Ling Lin, James C. Liao and Han-Chung Wu
    Citation: Journal of Biomedical Science 2021 28:43
    Content type: Research Published on:

  3. The evolution of cartilage degeneration is still not fully understood, partly due to its thinness, low radio-opacity and therefore lack of adequately resolving imaging techniques. X-ray phase-contrast imaging ...

    Authors: Annie Horng, Johannes Stroebel, Tobias Geith, Stefan Milz, Alexandra Pacureanu, Yang Yang, Peter Cloetens, Goran Lovric, Alberto Mittone, Alberto Bravin and Paola Coan
    Citation: Journal of Biomedical Science 2021 28:42
    Content type: Research Published on:

  6. Mesenchymal stem cells (MSCs) have been demonstrated to have a great potential in the treatment of several diseases due to their differentiation and immunomodulatory capabilities and their ability to be easily...

    Authors: Jana Janockova, Lucia Slovinska, Denisa Harvanova, Timea Spakova and Jan Rosocha
    Citation: Journal of Biomedical Science 2021 28:39
    Content type: Review Published on:

  7. Histone deacetylase (HDAC) inhibition was reported to ameliorate lung fibrosis in animal models. However, little is known about the underlying mechanism of HDAC7 in the regulation of CTGF production in lung fi...

    Authors: Hung-Sheng Hua, Heng-Ching Wen, Chih-Ming Weng, Hong-Sheng Lee, Bing-Chang Chen and Chien-Huang Lin
    Citation: Journal of Biomedical Science 2021 28:38
    Content type: Research Published on:

  8. Low cardiorespiratory fitness (V̇O2peak) is highly associated with chronic disease and mortality from all causes. Whilst exercise training is recommended in health guidelines to improve V̇O2peak, there is conside...

    Authors: Camilla J. Williams, Zhixiu Li, Nicholas Harvey, Rodney A. Lea, Brendon J. Gurd, Jacob T. Bonafiglia, Ioannis Papadimitriou, Macsue Jacques, Ilaria Croci, Dorthe Stensvold, Ulrik Wisloff, Jenna L. Taylor, Trishan Gajanand, Emily R. Cox, Joyce S. Ramos, Robert G. Fassett…
    Citation: Journal of Biomedical Science 2021 28:37
    Content type: Research Published on:

  9. Fibrosis can be defined as an excessive and deregulated deposition of extracellular matrix proteins, causing loss of physiological architecture and dysfunction of different tissues and organs. In the skin, fib...

    Authors: Angelo Giuseppe Condorelli, May El Hachem, Giovanna Zambruno, Alexander Nystrom, Eleonora Candi and Daniele Castiglia
    Citation: Journal of Biomedical Science 2021 28:36
    Content type: Review Published on:

  11. The spread of SARS-CoV-2, the virus that causes Coronavirus Disease 2019 (COVID-19), has been characterized as a worldwide pandemic. Currently, there are few preclinical animal models that suitably represent i...

    Authors: Ssu-Hsueh Tseng, Brandon Lam, Yu Jui Kung, John Lin, Li Liu, Ya Chea Tsai, Louise Ferrall, Richard B. S. Roden, T. C. Wu and Chien-Fu Hung
    Citation: Journal of Biomedical Science 2021 28:34
    Content type: Research Published on:

  12. The Ras homolog gene family member A (RhoA) is the founding member of Rho GTPase superfamily originally studied in cancer cells where it was found to stimulate cell cycle progression and migration. RhoA acts a...

    Authors: Lucia Sophie Kilian, Jakob Voran, Derk Frank and Ashraf Yusuf Rangrez
    Citation: Journal of Biomedical Science 2021 28:33
    Content type: Review Published on:

  13. Leiomyosarcoma (LMS), the most common soft tissue sarcoma, exhibits heterogeneous and complex genetic karyotypes with severe chromosomal instability and rearrangement and poor prognosis.

    Authors: Po-Hsuan Su, Rui-Lan Huang, Hung-Cheng Lai, Lin-Yu Chen, Yu-Chun Weng, Chih-Chien Wang and Chia-Chun Wu
    Citation: Journal of Biomedical Science 2021 28:32
    Content type: Research Published on:

  14. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Fang Wang, Xiaochun Wang, Jingruo Li, Pengwei Lv, Mingli Han, Lin Li, Zhuo Chen, Lingling Dong, Nan Wang and Yuanting Gu
    Citation: Journal of Biomedical Science 2021 28:31
    Content type: Correction Published on:

    The original article was published in Journal of Biomedical Science 2021 28:4

  15. A brain organoid is a self-organizing three-dimensional tissue derived from human embryonic stem cells or pluripotent stem cells and is able to simulate the architecture and functionality of the human brain. B...

    Authors: Nan Sun, Xiangqi Meng, Yuxiang Liu, Dan Song, Chuanlu Jiang and Jinquan Cai
    Citation: Journal of Biomedical Science 2021 28:30
    Content type: Review Published on:

  16. Due to the difficulties in early diagnosing and treating hepatocellular carcinoma (HCC), prognoses for patients remained poor in the past decade. In this study, we established a screening model to discover nov...

    Authors: Yi-Chieh Yang, Ming-Hsien Chien, Tsung-Ching Lai, Min-Che Tung, Yi-Hua Jan, Wei-Ming Chang, Shih-Ming Jung, Ming-Huang Chen, Chun-Nan Yeh and Michael Hsiao
    Citation: Journal of Biomedical Science 2021 28:29
    Content type: Research Published on:

  17. Mesenchymal stem/stromal cells (MSCs) are a promising resource for cell-based therapy because of their high immunomodulation ability, tropism towards inflamed and injured tissues, and their easy access and iso...

    Authors: Wei-Zhan Zhuang, Yi-Heng Lin, Long-Jyun Su, Meng-Shiue Wu, Han-Yin Jeng, Huan-Cheng Chang, Yen-Hua Huang and Thai-Yen Ling
    Citation: Journal of Biomedical Science 2021 28:28
    Content type: Review Published on:

  19. Breast cancer is the most diagnosed malignancy in women. Increasing evidence has highlighted the importance of chronic inflammation at the local and/or systemic level in breast cancer pathobiology, influencing...

    Authors: Sara Socorro Faria, Susan Costantini, Vladmir Cláudio Cordeiro de Lima, Victor Pianna de Andrade, Mickaël Rialland, Rebe Cedric, Alfredo Budillon and Kelly Grace Magalhães
    Citation: Journal of Biomedical Science 2021 28:26
    Content type: Review Published on:

  20. Cardiovascular diseases (CVDs) are considered the predominant cause of morbidity and mortality globally. Of these, myocardial infarction (MI) is the most common cause of CVD mortality. MI is a life-threatening...

    Authors: Chanon Piamsiri, Chayodom Maneechote, Natthaphat Siri-Angkul, Siriporn C. Chattipakorn and Nipon Chattipakorn
    Citation: Journal of Biomedical Science 2021 28:25
    Content type: Review Published on:

  21. Thyroid hormone analogues—particularly, l-thyroxine (T4) has been shown to be relevant to the functions of a variety of cancers. Integrin αvβ3 is a plasma membrane structural protein linked to signal transduction...

    Authors: Yu-Chen S. H. Yang, Po-Jui Ko, Yi-Shin Pan, Hung-Yun Lin, Jacqueline Whang-Peng, Paul J. Davis and Kuan Wang
    Citation: Journal of Biomedical Science 2021 28:24
    Content type: Review Published on:

  22. To evaluate the impact of hepatitis C virus (HCV) elimination via interferon (IFN)-based therapy on gene expression profiles related to the immune system in HIV/HCV-coinfected patients.

    Authors: Óscar Brochado, Isidoro Martínez, Juan Berenguer, Luz Medrano, Juan González-García, María Ángeles Jiménez-Sousa, Ana Carrero, Víctor Hontañón, Jordi Navarro, Josep M. Guardiola, Amanda Fernández-Rodríguez and Salvador Resino
    Citation: Journal of Biomedical Science 2021 28:23
    Content type: Research Published on:

  23. Obesity-related cardiovascular risk, end points, and mortality are strongly related to arterial stiffening. Current therapeutic approaches for arterial stiffening are not focused on direct targeting within the...

    Authors: Ju-Yi Chen, Yi-Pin Wu, Chih-Yi Li, Huei-Fen Jheng, Ling-Zhen Kao, Ching-Chun Yang, Sy-Ying Leu, I-Chia Lien, Wen-Tsan Weng, Haw-Chih Tai, Yu-Wei Chiou, Ming-Jer Tang, Pei-Jane Tsai and Yau-Sheng Tsai
    Citation: Journal of Biomedical Science 2021 28:22
    Content type: Research Published on:

  24. Breast cancer is the most common solid cancer that affects female population globally. MicroRNAs (miRNAs) are short non-coding RNAs that can regulate post-transcriptional modification of multiple downstream ge...

    Authors: Zhi Xiong Chong, Swee Keong Yeap and Wan Yong Ho
    Citation: Journal of Biomedical Science 2021 28:21
    Content type: Review Published on:

  25. Previous study disclosed Fucosyltransferase 2 (Fut2) gene as a IBD risk locus. This study aimed to explore the mechanism of Fut2 in IBD susceptibility and to propose a new strategy for the treatment of IBD.

    Authors: Xuelian Tang, Weijun Wang, Gaichao Hong, Caihan Duan, Siran Zhu, Yuen Tian, Chaoqun Han, Wei Qian, Rong Lin and Xiaohua Hou
    Citation: Journal of Biomedical Science 2021 28:20
    Content type: Research Published on:

  26. The bile salt export pump (BSEP) is a pivotal apical/canalicular bile salt transporter in hepatocytes that drives the bile flow. Defects in BSEP function and canalicular expression could lead to a spectrum of ...

    Authors: Shang-Hsin Wu, Mei-Hwei Chang, Ya-Hui Chen, Hui-Lin Wu, Huey-Huey Chua, Chin-Sung Chien, Yen-Hsuan Ni, Hui-Ling Chen and Huey-Ling Chen
    Citation: Journal of Biomedical Science 2021 28:19
    Content type: Research Published on:

  27. Glioblastoma is the most common primary malignant brain tumor that is usually considered fatal even with treatment. This is often a result for tumor to develop resistance. Regarding the standard chemotherapy, ...

    Authors: Chia-Hung Chien, Wei-Ting Hsueh, Jian-Ying Chuang and Kwang-Yu Chang
    Citation: Journal of Biomedical Science 2021 28:18
    Content type: Review Published on:

  28. Innate immunity is the first line of host defense against viral infection. After invading into the cells, pathogen-associated-molecular-patterns derived from viruses are recognized by pattern recognition recep...

    Authors: Rongzhao Zhang, Zhixin Li, Yan-Dong Tang, Chenhe Su and Chunfu Zheng
    Citation: Journal of Biomedical Science 2021 28:17
    Content type: Review Published on:

  29. Galectins are animal lectins that recognize carbohydrates and play important roles in maintaining cellular homeostasis. Recent studies have indicated that under a variety of challenges, intracellular galectins...

    Authors: Ming-Hsiang Hong, I-Chun Weng, Fang-Yen Li, Wei-Han Lin and Fu-Tong Liu
    Citation: Journal of Biomedical Science 2021 28:16
    Content type: Review Published on:

  30. Although rheumatoid arthritis affects 1% of the global population, the role of rheumatoid cachexia, which occurs in up to a third of patients, is relatively neglected as research focus, despite its significant...

    Authors: T. Ollewagen, K. H. Myburgh, M. van de Vyver and C. Smith
    Citation: Journal of Biomedical Science 2021 28:15
    Content type: Review Published on:

  31. Glutaminase isoenzymes GLS and GLS2 play apparently opposing roles in cancer: GLS acts as an oncoprotein, while GLS2 (GAB isoform) has context specific tumour suppressive activity. Some microRNAs (miRNAs) have...

    Authors: Juan de los Santos-Jiménez, José A. Campos-Sandoval, Clara Márquez-Torres, Nieves Urbano-Polo, David Brøndegaard, Mercedes Martín-Rufián, Carolina Lobo, Ana Peñalver, María C. Gómez-García, Janet Martín-Campos, Carolina Cardona, Laura Castilla, Felipe da Costa Souza, Tzuling Cheng, Juan A. Segura, Francisco J. Alonso…
    Citation: Journal of Biomedical Science 2021 28:14
    Content type: Research Published on:

  32. Although the availability of therapeutic options including temozolomide, radiotherapy and some target agents following neurosurgery, the prognosis of glioma patients remains poor. Thus, there is an urgent nee...

    Authors: Hong-Qing Cai, Min-Jie Zhang, Zhi-Jian Cheng, Jing Yu, Qing Yuan, Jin Zhang, Yan Cai, Li-Yan Yang, Yu Zhang, Jia-Jie Hao, Ming-Rong Wang and Jing-Hai Wan
    Citation: Journal of Biomedical Science 2021 28:13
    Content type: Research Published on:

  33. Helicobacter pylori-mediated gastric carcinogenesis is initiated by a plethora of signaling events in the infected gastric epithelial cells (GECs). The E3 ubiquitin ligase seven in absentia homolog 2 (Siah2) is i...

    Authors: Pragyesh Dixit, Shrikant B. Kokate, Indrajit Poirah, Debashish Chakraborty, Duane T. Smoot, Hassan Ashktorab, Niranjan Rout, Shivaram P. Singh and Asima Bhattacharyya
    Citation: Journal of Biomedical Science 2021 28:12
    Content type: Research Published on:

  34. Therapeutic antibodies are instrumental in improving the treatment outcome for certain disease conditions. However, to enhance their efficacy and specificity, many efforts are continuously made. One of the app...

    Authors: Tomasz Klaus and Sameer Deshmukh
    Citation: Journal of Biomedical Science 2021 28:11
    Content type: Review Published on:

  35. Viruses from the genus Enterovirus (EV) of the Picornaviridae family are known to cause diseases such as hand foot and mouth disease (HFMD), respiratory diseases, encephalitis and myocarditis. The capsid of EV is...

    Authors: Mohd Ishtiaq Anasir, Faisal Zarif and Chit Laa Poh
    Citation: Journal of Biomedical Science 2021 28:10
    Content type: Review Published on:

  36. Gaining further insights into SARS-CoV-2 routes of infection and the underlying pathobiology of COVID-19 will support the design of rational treatments targeting the life cycle of the virus and/or the adverse ...

    Authors: Ioannis P. Trougakos, Kimon Stamatelopoulos, Evangelos Terpos, Ourania E. Tsitsilonis, Evmorfia Aivalioti, Dimitrios Paraskevis, Efstathios Kastritis, George N. Pavlakis and Meletios A. Dimopoulos
    Citation: Journal of Biomedical Science 2021 28:9
    Content type: Review Published on:

  37. Congenital myopathy (CM) is a group of clinically and genetically heterogeneous muscle disorders, characterized by muscle weakness and hypotonia from birth. Currently, no definite treatment exists for CM. A de...

    Authors: Po-Jui Hsu, Horng-Dar Wang, Yung-Che Tseng, Shao-Wei Pan, Bonifasius Putera Sampurna, Yuh-Jyh Jong and Chiou-Hwa Yuh
    Citation: Journal of Biomedical Science 2021 28:8
    Content type: Research Published on:

  38. The comparative evolutionary genomics analysis was used to study the functions of novel Ka/Ks-predicted human exons in a zebrafish model. The Yulink (MIOS, Entrez Gene: 54,468), a conserved gene from zebrafish...

    Authors: Ming-Wei Kuo, Hsiu-Hui Tsai, Sheng-Hung Wang, Yi-Yin Chen, Alice L. Yu and John Yu
    Citation: Journal of Biomedical Science 2021 28:7
    Content type: Research Published on:

  40. The accumulation of lipid-laden macrophages, foam cells, within sub-endothelial intima is a key feature of early atherosclerosis. Siglec-E, a mouse orthologue of human Siglec-9, is a sialic acid binding lectin...

    Authors: Yaw-Wen Hsu, Fu-Fei Hsu, Ming-Tsai Chiang, Dong-Lin Tsai, Fu-An Li, Takashi Angata, Paul R. Crocker and Lee-Young Chau
    Citation: Journal of Biomedical Science 2021 28:5
    Content type: Research Published on:

  41. Circular RNAs (circRNAs) have caught increasing attentions and interests for their important involvement in cancer initiation and progression. This study aims to investigate the biological functions of circNOL...

    Authors: Fang Wang, Xiaochun Wang, Jingruo Li, Pengwei Lv, Mingli Han, Lin Li, Zhuo Chen, Lingling Dong, Nan Wang and Yuanting Gu
    Citation: Journal of Biomedical Science 2021 28:4
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2021 28:31

  42. Successful pregnancy is supported by a healthy maternal–fetal interface (i.e., the decidual tissues) which holds the conceptus and safeguards it against stressors from the beginning of pregnancy. Any disturban...

    Authors: Paz de la Torre, Miguel Fernández-de la Torre and Ana I. Flores
    Citation: Journal of Biomedical Science 2021 28:3
    Content type: Research Published on:

  43. The homologous recombination (HR) pathway is involved in DNA damage response (DDR), which is crucial to cancer cell survival after treatment with DNA damage agents. O6-methylguanine DNA methyltransferase (MGMT...

    Authors: Shang-Hung Chen, Wen-Tsung Huang, Wan-Chen Kao, Sheng-Yen Hsiao, Hsin-Yi Pan, Chin-Wen Fang, Yow-Ling Shiue, Chia-Lin Chou and Chien-Feng Li
    Citation: Journal of Biomedical Science 2021 28:2
    Content type: Research Published on:

  44. Emergence of Candida glabrata, which causes potential life-threatening invasive candidiasis, has been widely associated with high morbidity and mortality. In order to cause disease in vivo, a robust and highly ef...

    Authors: Shu Yih Chew, Alistair J. P. Brown, Benjamin Yii Chung Lau, Yoke Kqueen Cheah, Kok Lian Ho, Doblin Sandai, Hassan Yahaya and Leslie Thian Lung Than
    Citation: Journal of Biomedical Science 2021 28:1
    Content type: Research Published on:

  45. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a new type of coronavirus that causes the Coronavirus Disease 2019 (COVID-19), which has been the most challenging pandemic in this century. Cons...

    Authors: Yen-Der Li, Wei-Yu Chi, Jun-Han Su, Louise Ferrall, Chien-Fu Hung and T.-C. Wu
    Citation: Journal of Biomedical Science 2020 27:104
    Content type: Review Published on:

  46. Dendritic spines, the actin-rich protrusions emerging from dendrites, are the subcellular locations of excitatory synapses in the mammalian brain. Many actin-regulating molecules modulate dendritic spine morph...

    Authors: Hsiao-Tang Hu, Tzyy-Nan Huang and Yi-Ping Hsueh
    Citation: Journal of Biomedical Science 2020 27:103
    Content type: Research Published on:

  47. Peroxisome proliferator activated receptor gamma (PPARG) belongs to the nuclear receptor superfamily functioning as transcription factors to regulate cellular differentiation, development and metabolism. Moreover...

    Authors: Maria García-Ricobaraza, Mercedes García-Bermúdez, Francisco J. Torres-Espinola, M. Teresa Segura Moreno, Mathieu N. Bleyere, Ligia E. Díaz-Prieto, Esther Nova, Ascensión Marcos and Cristina Campoy
    Citation: Journal of Biomedical Science 2020 27:101
    Content type: Research Published on:

  48. Esophageal squamous cell carcinoma (ESCC) is widely prevalent in Taiwan, and high metastatic spread of ESCC leads to poor survival rate. Fibronectin (FN) assembly on the cell membrane may induce ESCC mobility....

    Authors: Hong-Yi Chang, Chi-Hua Lee, Yi-Syuan Li, Jing-Tong Huang, Sheng-Hui Lan, Yi-Fang Wang, Wu-Wei Lai, Yi-Ching Wang, Yan-Ju Lin, Hsiao-Sheng Liu and Hung-Chi Cheng
    Citation: Journal of Biomedical Science 2020 27:102
    Content type: Research Published on:

  49. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Nithya Subramanian, Jagat R. Kanwar, Prasanna kumar Athalya, Narayanan Janakiraman, Vikas Khetan, Rupinder K. Kanwar, Sailaja Eluchuri and Subramanian Krishnakumar
    Citation: Journal of Biomedical Science 2020 27:100
    Content type: Correction Published on:

    The original article was published in Journal of Biomedical Science 2015 22:4

  50. Global ischemia is the resulting effect of a cardiopulmonary arrest (CPA). Presently there is no effective treatment to address neurological deficits in patients who survived a CPA. Granulocyte-colony stimulat...

    Authors: Janet M. Menzie-Suderam, Jigar Modi, Hongyaun Xu, Andrew Bent, Paula Trujillo, Kristen Medley, Eugenia Jimenez, Jessica Shen, Michael Marshall, Rui Tao, Howard Prentice and Jang-Yen Wu
    Citation: Journal of Biomedical Science 2020 27:99
    Content type: Research Published on:
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Journal of Biomedical Science

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