Table 1 Electrophysiological properties of healthy and myopathic LA-PV cardiomyocytes isolated from 18 healthy and 17 myopathic Syrian hamsters
Myopathic | Healthy | |
|---|---|---|
Cm(pF) | 47 ± 3*(67) | 33 ± 2 (83) |
APA (mV) | 81 ± 3 (29) | 87 ± 2 (42) |
Phase-0 | 14.1 ± 2.1*(25) | 24.2 ± 1.9(34) |
MDP (-mV) | 60 ± 1 (29) | 57 ± 1 (42) |
APD20 (msec) | 21 ± 3 (29) | 26 ± 3 (42) |
APD50 (msec) | 40 ± 5* (29) | 64 ± 9 (42) |
APD90 (msec) | 77 ± 8* (29) | 109 ± 11 (42) |
(mV/ms)- Cm, membrane capacitance of myocyte. For action potential parameters: Steady-state (driven at 1 Hz) values are given in mean ± S.E.M. APA, action potential amplitude. Phase-0
(mV/ms), maximum dV/dt of phase-0 depolarization. MDP, maximum diastolic potential; APD20, APD50, and APD90: action potential duration at 20%, 50% and 90%, respectively, of repolarization levels. Number in parenthesis indicates number of myocytes. *P < 0.05 by group comparisons between healthy and myopathic hamsters.