| |
Myopathic
|
Healthy
|
|---|
|
Cm(pF)
|
47 ± 3*(67)
|
33 ± 2 (83)
|
|
APA (mV)
|
81 ± 3 (29)
|
87 ± 2 (42)
|
Phase-0  (mV/ms)
|
14.1 ± 2.1*(25)
|
24.2 ± 1.9(34)
|
|
MDP (-mV)
|
60 ± 1 (29)
|
57 ± 1 (42)
|
|
APD20 (msec)
|
21 ± 3 (29)
|
26 ± 3 (42)
|
|
APD50 (msec)
|
40 ± 5* (29)
|
64 ± 9 (42)
|
|
APD90 (msec)
|
77 ± 8* (29)
|
109 ± 11 (42)
|
- Cm, membrane capacitance of myocyte. For action potential parameters: Steady-state (driven at 1 Hz) values are given in mean ± S.E.M. APA, action potential amplitude. Phase-0 (mV/ms), maximum dV/dt of phase-0 depolarization. MDP, maximum diastolic potential; APD20, APD50, and APD90: action potential duration at 20%, 50% and 90%, respectively, of repolarization levels. Number in parenthesis indicates number of myocytes. *P < 0.05 by group comparisons between healthy and myopathic hamsters.
(mV/ms)